This $485,375 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will support the development and evaluation of a 3D engineered muscle tissue model to study the metabolic response to muscle contraction in the context of aging. The University of Washington, a prominent research institution, will lead this 2-year project to: 1) examine the mitochondrial mechanisms underlying the decreased metabolic response to muscle contraction in aged human 3D engineered...
This $485,375 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will fund research at the University of Washington to investigate genomic alterations in skeletal muscle associated with aging. The key objectives are to: Explore if alternative splicing of mRNA results in quantitative differential isoform changes associated with aging, potentially leading to increased expression of non-functional proteins relevant for healthy muscle function. The researchers...
This Project Grant award from the National Institute on Aging's Aging Research program (CFDA 93.866) provides $572,203 to the Regents of the University of Michigan to conduct research on mechanisms for preserving muscle function during aging. The research aims to define cellular responses and molecular pathways critical for motor unit expansion, a compensatory mechanism that helps maintain muscle under conditions of denervation. Specifically, the project will examine how aging and denervation...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to the University of Texas Medical Branch at Galveston is funding research to investigate the effects of age-related post-translational modifications on the stability and function of the myosin protein and its chaperone UNC-45. The $576,893 award, spanning September 2024 to May 2029, aims to elucidate how these chemical modifications contribute to the loss of muscle mass and function associated with...
This $126,042 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research into the cell autonomous and cell non-autonomous roles of mitochondrial proline catabolism for muscle-mitochondrial health and overall organismal longevity. The University of Southern California is the primary awardee and will employ innovative techniques, including CRISPR/Cas9 genetic editing, single-cell RNA sequencing, and mitochondrial assessments, to comprehensively...
This $161,922 Project Grant award from the National Institute on Aging's Aging Research program (CFDA 93.866) will support research to investigate the mechanisms by which mitochondrial protein import stress can induce the release of myokines, which are proteins secreted by muscle cells that promote metabolic and cardiovascular health. The two-year project, led by The Research Foundation for the State University of New York's Upstate Medical Center, aims to uncover the specific transcriptional...
This Project Grant award of $141,890 from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to examine the role of the MYC gene in skeletal muscle function, metabolism, and cellular dynamics across the lifespan. The funded research will leverage mouse models to: 1) Conduct functional, bioenergetic, and cellular analyses; 2) Perform single-cell RNA sequencing of muscle fiber nuclei; and 3) Analyze global DNA methylation and methylation clocks in muscle nuclei. The research...
This federal Project Grant award R01AG087565 from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $3,343,725.00 to investigate the opposing effects of extracellular matrix aging and muscle activity on extracellular vesicle promotion of muscle regeneration. The award period runs from August 15, 2024 to April 30, 2029. The key objectives are to: 1) Examine how aging of the skeletal muscle extracellular matrix alters the molecular cargoes of muscle-derived extracellular...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) for $402,500 supports research on the role of glutamine metabolism in regulating muscle stem cell function. The award, which runs from September 2024 to August 2025, will be carried out by Duke University's Office of Research Administration Division. The key objectives are to: 1) test the hypothesis that glutamine-driven "bidirectional" metabolism, involving both oxidative and reductive...
This $1,031,595 project grant from the National Institute on Aging, part of the Department of Health and Human Services, supports research under the Aging Research program (CFDA 93.866). The awardee, Dana-Farber Cancer Institute, will define the landscape and mechanisms of protein redox regulation during aging. Specifically, the Institute will systematically map cysteine oxidation networks in mouse tissues to determine their role in coordinating protein complex assemblies relevant to age-related...