This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $687,422 to the Benaroya Research Institute at Virginia Mason to conduct research focused on CD4+ tissue resident memory T cells and their role in the pathogenesis of multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE). The key objectives are to: 1) characterize the diversity...
This three-year $872,936 project grant from the National Institute of Allergy and Infectious Diseases, part of the Department of Health and Human Services, will fund research into the regulation of the microglial neuroimmune response by long non-coding RNAs. The grantee, Creighton University, will investigate how specific long intergenic non-coding RNAs (lincRNAs) mediate a proinflammatory state in microglia and determine if differential lincRNA expression underlies viral-induced mouse models of...
This $427,627 federal Project Grant awarded by the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports research to investigate how gamma herpesvirus infection impacts key pathogenic interactions between B cells and CD4 T cells in a mouse model of multiple sclerosis (MS). The research aims to determine how viral infection affects B cells' support of disease-driving CD4 T cells, and how this impacts B cell-dependent versus B...
This Project Grant award of $158,260 from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports research to investigate the role of enteric glial cells (EGCs) in the autoimmune disorder multiple sclerosis (MS). The award recipient, the Rector & Visitors of the University of Virginia, will conduct experiments to characterize T cell responses against EGCs in an experimental autoimmune encephalomyelitis (EAE) model, as well...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), will support the development and high-content screening of a library of over 50,000 bifunctional interferon chimera proteins. The goal is to identify and validate improved cell stimulatory functions of these protein chimeras, which have potential applications for treating conditions like multiple sclerosis. The $807,664 award...
This federal Project Grant award of $791,864 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to identify molecular factors controlling chromatin organization and gene regulation in the malaria parasite Plasmodium falciparum. The research aims to elucidate the importance of long non-coding RNAs (lncRNAs) in parasite development, virulence, and sexual differentiation, with the goal...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, is focused on developing a software platform to automate the analysis of quantitative MRI biomarkers for monitoring and staging multiple sclerosis (MS). The $353,942 award to Microstructure Imaging Inc., with a project period from September 2024 to August 2026, aims to: 1) curate...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $565,149 to Health Research, Inc. Wadsworth Center Division to conduct research on RNA-based regulatory mechanisms in Mycobacterium tuberculosis (MTB). The primary objectives are to: Define the regulatory interactions of the sRNA MCR11 and its impact on gene expression in MTB. Characterize the roles of RNA-ABMR...
This Project Grant award of $1,454,386.00 from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports fundamental research to better understand the epigenetic regulation of the HIV-1 viral RNA cap. The research aims to define the structural basis of HIV cap hypermethylation and its linkage to modulating host innate immune signaling, with the goal of developing new treatments to neutralize deleterious...
This Project Grant award of $790,222 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research Program (CFDA 93.855) supports research by the Van Andel Research Institute (VAI) to investigate how the enzyme methionine adenosyltransferase 2A (MAT2A) regulates the differentiation and function of pathogenic T helper (Th) cells versus protective regulatory T (Treg) cells in the context of central nervous system autoimmunity, such as...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $979,138 to Decode Health, Inc. to conduct research on identifying RNA biomarkers that can distinguish between relapsing-remitting, primary progressive, and secondary progressive forms of multiple sclerosis (MS). The goal is to develop a multivariate machine learning-based blood test that can improve the diagnosis and monitoring of MS subtypes, which is critical for selecting appropriate therapies and managing disease progression. The award period runs from August 1, 2025 to July 31, 2027.