This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $687,422 to the Benaroya Research Institute at Virginia Mason to conduct research focused on CD4+ tissue resident memory T cells and their role in the pathogenesis of multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE). The key objectives are to: 1) characterize the diversity...
This Project Grant award of $158,260 from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports research to investigate the role of enteric glial cells (EGCs) in the autoimmune disorder multiple sclerosis (MS). The award recipient, the Rector & Visitors of the University of Virginia, will conduct experiments to characterize T cell responses against EGCs in an experimental autoimmune encephalomyelitis (EAE) model, as well...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research conducted by the Scripps Research Institute to identify small molecule compounds that can selectively induce the differentiation of functional regulatory T cells (Tregs). The $417,984 award, effective March 7, 2025 through February 28, 2026, aims to: 1) determine the mechanism of action and optimize the...
This $427,627 federal Project Grant awarded by the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports research to investigate how gamma herpesvirus infection impacts key pathogenic interactions between B cells and CD4 T cells in a mouse model of multiple sclerosis (MS). The research aims to determine how viral infection affects B cells' support of disease-driving CD4 T cells, and how this impacts B cell-dependent versus B...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $464,750 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the Icahn School of Medicine at Mount Sinai (ISMMS) to conduct research on understanding and modulating the plasticity of T-helper 17 (Th17) cells. The research project aims to decipher the activity signatures of the AMP-activated protein kinase (AMPK) and its role in driving the transdifferentiation of Th17 cells into...
This Project Grant award of $305,000.00 from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to investigate the role of stem-like T cells in multiple sclerosis (MS) disease progression. The key objectives are to: Rigorously test the hypothesis that a continuing stemness and differentiation of CD4+ T stem cells results in functional and transcriptomic diversification under evolving...
This Project Grant award, valued at $162,000.00, was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The award supports research at Indiana University Indianapolis to investigate the role of TGF-beta signaling in regulating T follicular helper (Tfh) cell differentiation and mast cell function, with the goal of better understanding the pathogenesis of allergic diseases. Key objectives include...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $657,673 to the Regents of the University of Minnesota to conduct research on non-deletional CD8+ T cell tolerance. The research aims to define the gene regulation that inhibits self-reactive CD8+ T cells and classify different types of self-reactive CD8+ T cell clones, in order to understand which tolerance...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $221,888 to the University of New Mexico Health Sciences Center to study the control of survival pathways in Th17 cells. The research aims to explore mechanisms for inducing Th17 cell apoptosis and evaluate potential applications of this approach using preclinical animal models. The award period runs from January 22,...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) provides $3,428,212 to St. Jude Children's Research Hospital Inc. from July 2025 through June 2029 to conduct research on the "Epigenetic Checkpoint Regulation of Naive T-Cell Quiescence and Peripheral Tolerance". The research aims to understand how intrinsic checkpoint regulators, specifically the ascorbate-TET axis, maintain naive T-cell...