This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $427,627 to The University of Iowa to investigate how gamma herpesvirus (GHV) infection impacts B cell-dependent interactions that drive autoimmune demyelinating disease in a mouse model of multiple sclerosis (MS). The research aims to determine how GHV infection, such as Epstein-Barr virus, affects B cells' support of disease-driving CD4 T cells, and how this impacts B cell-dependent versus B cell-independent experimental autoimmune encephalomyelitis (EAE) in mice. This 2-year project, running from July 1, 2025 to June 30, 2027, will leverage the university's expertise to develop a novel mouse model that can better dissect the role of pathogenic B cell-CD4 T cell interactions in autoimmune demyelinating disease in the context of viral infection, providing insights that may inform future MS treatment approaches.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $427.6k | 6/25/25 |