This $220,224 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports computational research on the assembly, maturation, and uncoating processes of the HIV-1 virus. The University of Chicago, the grant recipient, will investigate factors beyond the viral capsid that influence critical morphological transitions in the HIV-1 life cycle, such as the role of host cell factors and...
This $223,300 federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to develop novel HIV capsid-targeting antivirals that can maintain activity against lenacapavir-resistant HIV viruses. The primary award recipient, Emory University, is conducting studies to synthesize and characterize analogs of a lead compound that can bind the HIV capsid more effectively in...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) aims to investigate the role of the PCIF1 protein in regulating host-HIV interactions. The $502,861 award will support research to define the dynamics and mapping of human N6,2'-O-dimethyladenosine (m6Am) RNA methylation during HIV infection and methamphetamine exposure, determine how HIV alters the m6Am methylome of host...
This federal Project Grant award, provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), is supporting a study of acute HIV infection to investigate strategies for HIV eradication. The $794,045 award to The Regents of the University of California, San Francisco (UCSF) aims to identify host cellular mechanisms that drive HIV reservoir decay and sustained viral control, with the goal of informing...
This federal Project Grant award of $571,685, provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to investigate the architecture and dynamics of the immature HIV lattice. The key objectives are to: Examine the effects of non-Gag HIV components on the stability of the immature lattice and determine the biomolecular forces involved. Understand how dynamics within the lattice drive...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded Emory University a $653,693 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to conduct research on the structural details of HIV-1 assembly and the mechanism of the capsid targeting compound lenacapavir. The key objectives are to: 1) Develop single particle cryo-electron microscopy techniques to study the immature and mature HIV-1 Gag and capsid lattices, providing insights into the...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $752,745 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the University of Massachusetts Medical School (UMass Medical) to conduct research on the dynamics and evolution of HIV Gag and GagPol processing. The research aims to use molecular dynamics simulations, single-molecule FRET imaging, and cryo-electron tomography to probe the structural and dynamic features of Gag and GagPol...
This federal Project Grant award, valued at $2,535,942.00 and funded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to investigate the viral and host determinants of donor-specific anti-HIV/SIV immunity mediated by APOBEC3 enzymes. The research aims to integrate diverse viral and host datasets and use computational and experimental techniques to identify the molecular determinants of...
This $474,620 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), will fund research at the University of California, San Francisco (UCSF) to comprehensively define the selective pressures on the HIV-1 capsid. The project aims to use a high-throughput saturating mutagenesis approach to identify capsid mutations that allow the virus to evade human restriction factors, as well as those...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $176,096 Project Grant under the Allergy and Infectious Diseases Research (CFDA 93.855) program to the University of Illinois to develop a computational toolkit for dissecting HIV drug resistance mechanisms and designing countermeasures. The project aims to leverage protein conformational dynamics to rigorously quantify how specific residues and interactions contribute to drug resistance, enabling the rational design...