Project Grant R43HD102245

The National Heart, Lung, and Blood Institute (NHLBI), under the federal Cardiovascular Diseases Research program (CFDA 93.837), awarded a $306,643 project grant to Mira Medical, LLC to develop a new extracorporeal membrane oxygenation (ECMO) pump designed to efficiently accommodate the low flow rates needed for pediatric and neonatal patients. The project aims to design, develop, and test a low-flow ECMO pump capable of operating at flow rates from 0.05 to 0.5 L/min, which is an order of...

This STTR Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) provides $294,063 to Biomembretics, Inc. to develop and demonstrate a high-volume manufacturing technology for microfluidic oxygenators for extracorporeal membrane oxygenation (ECMO) to treat respiratory failure. The project aims to advance a bioinspired microfluidic oxygenator technology that can safely and effectively oxygenate blood, addressing limitations of the...

This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) provides $295,924 to Convergent Engineering, Inc. to develop a prototype decision support system for personalized mechanical ventilation care. The system aims to simplify the use of esophageal pressure measurements to optimize ventilator settings and prevent complications for ventilated patients. The project has two key objectives: 1) Building a...

This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), supports the development of a novel bearingless (magnetically levitated) flux reversal motor for neonatal and pediatric extracorporeal life support applications. The $870,467 award to Ension Inc. aims to extend the operating range of this innovative blood pump technology to meet the high pressure and low flow requirements for cardiac and...

This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) provides $117,750 to the Ann & Robert H Lurie Children's Hospital of Chicago to develop and validate the use of wireless biosensors and a portable capnograph device for remote patient monitoring of children on long-term invasive home mechanical ventilation. The project aims to address limitations of the hospital's current hand-collected vital sign data approach by...

This Project Grant award from the National Heart Lung and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) aims to develop a modern Electrical Impedance Tomography (EIT) device for monitoring children in the Intensive Care Unit (ICU). The $299,900 award to Goodlife Inventors LLC will fund efforts to (1) generate initial designs for an advanced lightweight EIT belt and (2) assess the technical feasibility of a miniaturized, easier to use EIT core device. If...

This Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the federal Child Health and Human Development Extramural Research program (CFDA 93.865), provides $866,579 to The Children's Hospital of Philadelphia (CHOP) to evaluate the effectiveness of an "Optimizing Ventilation (OPTI-VENT) Bundle" in improving cardiac arrest outcomes among children. The OPTI-VENT Bundle consists of provider education and...

The National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), awarded a $1,013,000 Project Grant to Endolynx Inc. to develop an Optical Sensor-Enabled Endotracheal Tube (OS-ETT). The goal of this SBIR Phase I project is to demonstrate the feasibility of the OS-ETT, which aims to reduce the risk and incidence of esophageal intubation and unintended extubation during the over 30 million intubations performed annually in the U.S. The OS-ETT...

This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $163,760 to Tufts Medical Center to conduct research on how veno-arterial extracorporeal membrane oxygenation (VA-ECMO) affects ventricular-vascular coupling in the context of acute myocardial infarction (AMI). The research aims to determine how VA-ECMO alters afterload, identify strategies to mitigate increases in left...

This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under CFDA Program 93.837 - Cardiovascular Diseases Research, provides $180,174 to The Children's Hospital of Philadelphia (CHOP) to develop a framework for designing the next generation of pediatric acute respiratory distress syndrome (ARDS) clinical trials. The key objectives of this 5-year project are to: 1) compare heterogeneity of treatment effect analysis methodologies in a pediatric ARDS...