This federal Project Grant award from the National Institute of Child Health and Human Development (CFDA 93.865 - Child Health and Human Development Extramural Research) provides $812,343 to test the efficacy of teleconsultation in reducing serious safety events during prehospital care for critically ill infants and children. The award funds a multicenter, simulation-based randomized controlled trial to compare the impact of teleconsultation with pediatric emergency physicians (using video)...
This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) provides $117,750 to the Ann & Robert H. Lurie Children's Hospital of Chicago to develop and validate a remote patient monitoring system for children using home mechanical ventilation. The key objectives are to: 1) validate the use of wireless biosensors and a portable capnograph to continuously collect physiologic data, as an alternative to manual data collection by...
The National Institute of Child Health and Human Development (NICHD) awarded a 5-year, $163,080 Project Grant under the Child Health and Human Development Extramural Research program (CFDA 93.865) to the Ann & Robert H Lurie Children's Hospital of Chicago. The objective of this project is to develop and validate longitudinal machine learning-based prediction models that leverage high-frequency physiological monitor data and clinical variables to accurately identify children at risk of new or...
The National Heart, Lung, and Blood Institute (NHLBI), part of the National Institutes of Health (NIH), awarded a $889,188 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to The Children's Hospital Corporation (doing business as Boston Children's Hospital) to develop a new oxygen therapy called intravenous oxygen (IVO2) for the early resuscitation of cardiac arrest patients. The IVO2 therapy utilizes pH-responsive polymeric microbubbles to deliver high...
The National Institute of Child Health and Human Development (NICHD) awarded a $160,000 Project Grant under the Child Health and Human Development Extramural Research program (CFDA 93.865) to the University of California, Davis (UC Davis) to conduct a randomized trial comparing early rapid saline bolus volume replacement, standard neonatal resuscitation, and no volume replacement in a perinatal term ovine model of hypovolemic asphyxial cardiac arrest. The research aims to determine if early...
This $163,034 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) will support the development of deep learning-based artificial intelligence (AI) algorithms to improve resuscitation of out-of-hospital cardiac arrest (OHCA) patients. The principal investigator, Dr. Jason Coult, will leverage large retrospective datasets of OHCA defibrillator recordings to 1) design AI algorithms that can identify specific...
The National Institute of Child Health and Human Development (NICHD) awarded a $224,083 Project Grant (CFDA 93.865 - Child Health and Human Development Extramural Research) to Seattle Children's Hospital, doing business as Seattle Children's Research Institute, for the project "USE OF OSCILLOMETRY FOR THE EVALUATION OF PULMONARY FUNCTION FOLLOWING PEDIATRIC ACUTE RESPIRATORY FAILURE." The project period runs from May 1, 2025 to April 30, 2027. The funding will support research to...
The National Heart, Lung, and Blood Institute (NHLBI) awarded a $793,956 Project Grant (CFDA 93.837 - Cardiovascular Diseases Research) to Resuscitation Innovations LLC, doing business as Advancedcpr Solutions LLC, to develop innovations in CPR and aortic occlusion techniques to improve survival rates for patients experiencing refractory cardiac arrest. The project aims to address the significant unmet need, as nearly 750,000 out of the 800,000 annual cardiac arrest cases in the U.S. result in...
This federal Cooperative Agreement award, titled "Optimizing Pain Treatment in Children on Mechanical Ventilation (OPTICOM)", is funded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Drug Use and Addiction Research Programs (CFDA 93.279). The $6,842,922 award, beginning in Sep 2024 and running through Aug 2029, will support a large-scale, multi-site, double-blind, placebo-controlled clinical trial to evaluate the effectiveness of supplementing...
This federal Project Grant award of $198,720 from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research (CFDA 93.837) program supports research to understand the impact of invasive mechanical ventilation on functional fibrinolysis and thromboinflammation in critically ill children. The primary objectives are to determine how ventilation intensity affects fibrinolysis, identify plasma biomarkers of venous thromboembolism (VTE) risk, and develop an...