The National Heart, Lung, and Blood Institute (NHLBI) awarded a $873,736 project grant under the Cardiovascular Diseases Research program (CFDA 93.837) to Children's Hospital Los Angeles (CHLA) to study risk stratification markers for pediatric acute respiratory distress syndrome (ARDS). The project aims to validate the use of the end tidal alveolar dead space fraction (AVDSF) as a superior marker for mortality risk compared to oxygenation index (OI), as well as determine if AVDSF can identify...
This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $657,308 to The Children's Hospital of Philadelphia (CHOP) to conduct research on the CXCL12 signaling axis and its role in pulmonary arterial heterogeneity, development, and disease. The key objectives of this 12-month project are to: 1) define the spatiotemporal role of CXCL12 signaling in pulmonary vascular development, 2)...
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $797,130 to The Children's Hospital of Philadelphia (CHOP) from September 2024 to June 2028. The project aims to implement and evaluate the real-world effectiveness of "single maintenance and reliever therapy" (SMART) for managing moderate-to-severe childhood asthma in a predominantly Black pediatric population. The study uses a...
This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) provides $480,990 to the University of Illinois for a research project focused on accelerating alveolar epithelial regeneration to treat acute respiratory distress syndrome (ARDS). The key objectives are to investigate the role of "aerocytes", a newly identified capillary endothelial cell population, in regulating alveolar...
This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $844,386 to support research on the genetic landscape of childhood interstitial and diffuse lung diseases (CHILD). The key objectives are to: 1) Define molecular profiles of 300 CHILD lung biopsy samples to identify patient clusters with similar underlying causes, 2) Analyze whole exome sequence data from 400 children with...
This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) provides $188,740 to the University of Pittsburgh to conduct research on the impact of glycocalyx degradation on acute respiratory distress syndrome (ARDS) pathogenesis and outcomes. The research aims to: 1) estimate the attributable impact of glycocalyx degradation on ARDS patient outcomes, and 2) determine the longitudinal relationship between glycocalyx degradation...
This $782,362 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) supports research to investigate the role of TREK-1 potassium channels in acute respiratory distress syndrome (ARDS). The key objectives are to: 1) determine if ARDS decreases epithelial and endothelial TREK-1 levels, leading to cell membrane depolarization and calcium-dependent inflammation, and 2) evaluate if activating residual TREK-1...
This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $2,070,206 to Ann & Robert H Lurie Children's Hospital of Chicago to conduct research on endotypes of bronchopulmonary dysplasia (BPD) in premature infants. The research aims to leverage existing genetic and longitudinal clinical data from approximately 2,000 former premature children to characterize the long-term...
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) provides $737,815 to The Washington University to develop and validate an automated Electronic Health Record (EHR)-embedded system that can rapidly classify molecular phenotypes in patients with acute respiratory distress syndrome (ARDS) and sepsis. The goal is to enable precision medicine approaches in critical care by translating previously...
This is a Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), part of the National Institutes of Health (NIH), under the Cardiovascular Diseases Research (CFDA 93.837) program. The $827,682 award will fund a comprehensive research project to develop advanced imaging techniques, including dynamic contrast-enhanced CT, dual-energy CT, and electrical impedance tomography, to characterize pulmonary perfusion and guide personalized treatment of acute respiratory distress...