The National Heart, Lung, and Blood Institute (NHLBI) awarded a $163,760 Project Grant (CFDA 93.837 Cardiovascular Diseases Research) to Tufts Medical Center Parent, Inc. (doing business as Tufts Medical Center), a non-profit academic medical center in Boston, MA. The grant supports a 5-year research project to investigate how veno-arterial extracorporeal membrane oxygenation (VA-ECMO) alters ventricular-arterial coupling and myocardial workload in the setting of acute myocardial infarction. The study aims to define the mechanisms by which VA-ECMO increases left ventricular afterload and to test pharmacologic and device-based strategies to mitigate these effects and limit myocardial injury. The goal is to provide critical mechanistic and translational insights to improve outcomes for patients requiring VA-ECMO support due to cardiogenic shock following acute myocardial infarction.
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