Project Grant R43GM119941

This National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) Project Grant award of $275,000 to Delaqua Pharmaceuticals, Inc. aims to enhance the therapeutic use of hydrophobic drugs through a polymeric micelle approach to drug solubilization. The key objectives are to 1) improve the formulation of spherical micelles for enhanced stability and drug solubilization, 2) perform initial toxicity studies to establish the safety of the platform, and 3) demonstrate...

Superior Nano LLC received a $512,000 National Science Foundation Project Grant to develop dense nanolipid fluid systems for delivering drugs with poor bioavailability. The NSF funding supports research from June 2022 to May 2023 under the Technology, Innovation, and Partnerships program. This award will allow Superior Nano to advance scientific understanding of surfactant-lipid-water systems and create new knowledge applicable to manufacturing drug nanoparticles using twin-screw extrusion. By...

The National Science Foundation (NSF) awarded a $274,640 Project Grant under the NSF Technology, Innovation, and Partnerships (TIP) program (CFDA 47.084) to Protein Design Solutions LLC, a for-profit limited liability company located in Allentown, PA. The grant funding will support the development of a computational platform to predict and mitigate protein aggregation issues in the development of protein-based therapeutics. Specifically, the project aims to leverage state-of-the-art...

This three-year project grant from the National Science Foundation Division of Materials Research, totaling $306,307, will fund research into elucidating the rate-limiting steps of biopolymer dissolution and developing new biopolymer derivatives for oral drug delivery systems. Virginia Polytechnic Institute and State University, doing business as Virginia Tech, will lead the collaborative research effort to understand how additives impact the dissolution rates of polysaccharide derivatives....

Zaiput Flow Technologies LLC received a $275,000 Project Grant award from the National Science Foundation (NSF) under the NSF Technology, Innovation, and Partnerships program (CFDA 47.084) to develop an innovative, continuous crystallization device for pharmaceutical manufacturing. The goal is to improve the purification process of active pharmaceutical ingredients, which is a critical step used in over 90% of pharmaceutical production. The novel device aims to address scalability, cost, and...

This National Science Foundation (NSF) Engineering (CFDA 47.041) Project Grant award of $600,000 to the Rector & Visitors of the University of Virginia (UVA) aims to design innovative, biology-inspired adsorptive separation materials using peptides to purify new protein-based therapeutic medicines from contaminants. The project will leverage rationally designed short peptides to advance the molecular understanding of protein adsorption behaviors and establish design rules linking the...

This $350,000 Project Grant award from the National Center for Advancing Translational Sciences (NCATS), under the 93.350 CFDA program, supports the development of the Codomax EPI-MAX platform. This integrated omics and computational technology leverages cellular stress responses to enhance the production of difficult-to-express therapeutic proteins, with a focus on improving secretion and preventing aggregation in the Pichia pastoris expression system. The key products or services to be...

The National Center for Advancing Translational Sciences (NCATS) awarded a $275,000 Project Grant (CFDA 93.350) to Nectagen Inc. to develop bioprocess-compatible, second-generation nanoclamp affinity resins for the efficient purification of plasma-based therapeutic proteins. The goal is to identify panels of nanoclamps to 5 industrially relevant plasma-based therapeutics, select lead candidates, and optimize the resins for maximum recovery and purity from plasma samples. This project aims to...

The National Science Foundation awarded a $249,884 Project Grant to the Regents of the University of Minnesota under the NSF Technology, Innovation, and Partnerships federal grant program (CFDA 47.084) to develop a decentralized, on-demand production system for large volume parenteral solutions and medical fluids. The University will implement a proof-of-concept prototype capable of producing 100 L/hr of solutions such as electrolyte replacement, intravenous fluids, and dialysis mixtures on-site...

This National Science Foundation (NSF) Engineering (CFDA 47.041) Project Grant award to Lehigh University, in the amount of $199,999, aims to investigate the use of charged polymer complexes as a novel platform for dual drug delivery. The key objectives are: (1) complexing a charged degradable polymer with an oppositely charged peptide or protein; (2) monitoring the kinetics of the degradable polymer breakdown both as part of the complex and free in solution; and (3) incorporating a third...