Codomax Inc., a biotechnology company, received a $350,000 Project Grant award from the National Center for Advancing Translational Sciences (NCATS) under CFDA Program 93.350. The funding supports Codomax's research and development to optimize antibody production in Chinese Hamster Ovary (CHO) cells using its proprietary EPI-MAX technology platform. The project aims to enhance heavy and light chain expression by analyzing tRNA systems that limit antibody production and re-engineering the CREB1...
This Project Grant award from the National Science Foundation (NSF) under its Technology, Innovation, and Partnerships (TIP) program (CFDA 47.084) provides $275,000 to Tectaria Bio LLC to engineer cell lines with activated proteasomes for increased biomanufacturing efficiency. The project aims to test the feasibility and application of a novel technology to significantly increase the protein production capabilities of cell lines used in the manufacture of biologics, gene therapies, and vaccines....
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training Program (CFDA 93.859), provides $275,765 to Opera Bioscience, Inc. to develop a platform for cost-effective production of recombinant proteins and growth factors for therapeutic applications. The project aims to adapt Opera Bioscience's proprietary bacterial protein secretion technology to create an optimized, safe production strain and define an optimal...
This $358,640 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports the development of innovative computational approaches to infer cell-type-specific protein phenotypes from mass spectrometry-based proteogenomics data. The overarching goal is to enable deeper understanding of complex diseases by characterizing the protein-level dysregulation in different cell types present at disease sites....
This award from the National Science Foundation (NSF) under the Technology, Innovation, and Partnerships (TIP) program (CFDA 47.084) provides $303,864 to Core Biotherapeutics Inc., a for-profit organization, to develop a platform for designing disruptive drug candidates that can address high unmet medical needs. The project aims to determine the biological laws governing molecular networks that drive diseases and program these into an efficient, scalable algorithm for drug target discovery. This...
This $650,000 Project Grant awarded by the National Center for Advancing Translational Sciences (NCATS), under CFDA Program 93.350, supports research and development for a next generation probiotics-based platform technology to enable oral delivery of peptide and protein therapeutics. Specifically, the project aims to (1) develop an antibiotic-resistance-free expression system for stable, high-level production of therapeutic peptides in Lactobacillus probiotic strains, (2) create inducible...
This National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) Project Grant award of $274,640 to Protein Design Solutions LLC will fund the development of a computational platform to mitigate protein aggregation in the development of protein therapeutics. The project aims to validate and enhance the platform's ability to identify and suggest mitigation strategies for problematic aggregation sites in therapeutic proteins, which can impede efficacy and increase...
The National Institute of General Medical Sciences (NIGMS) awarded a $350,000 Project Grant (CFDA 93.859, Biomedical Research and Research Training) to GMJ Technologies, Inc., a minority-owned small disadvantaged business, to develop a high-resolution native capillary zone electrophoresis system with inline UV and native mass spectrometry capabilities. This innovative analytical technology is designed to enhance the characterization and quality control of protein therapeutics, such as monoclonal...
The federal Project Grant award R44GM154572 was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) to support the development and scale-up of Chromatan Inc.'s Continuous Countercurrent Tangential Chromatography (CCTC) platform for recombinant adeno-associated virus (rAAV) vector purification. The $5,037,617 award aims to commercialize the CCTC system, which promises to reduce downstream production costs...
This $350,000 project grant awarded by the National Science Foundation (NSF) Engineering program (CFDA 47.041) aims to develop a yeast strain with a robust protein secretion system that is tolerant to extreme pH and temperature levels. The primary objectives are to engineer the secretory pathway of the yeast Kluyveromyces marxianus using gene editing tools such as CRISPR, identify critical genes influencing protein production and secretion, and develop effective CRISPR libraries and selection...