Project Grant 2233759
- Zaiput Flow Technologies LLC received a $1.25M Cooperative Agreement from the National Science Foundation (NSF) under the Technology, Innovation, and Partnerships (TIP) program (CFDA 47.084) awarded on June 15, 2025. The SBIR Phase II project supports the development and commercialization of an innovative continuous crystallizer device designed to improve pharmaceutical manufacturing efficiency. The technology addresses critical gaps in active pharmaceutical ingredient (API) purification,...
- This Project Grant award from the National Science Foundation's (NSF) Engineering program (CFDA 47.041) provides $463,746 to the University of Puerto Rico Medical Sciences Campus (UPR-MSC) to study an innovative continuous crystallizer concept. The objective is to develop robust, scalable, and miniaturized equipment for pharmaceutical manufacturing that can improve resilience to supply chain disruptions and better meet fluctuating market needs. The research seeks to advance continuous...
- Superior Nano LLC received a $512,000 National Science Foundation Project Grant to develop dense nanolipid fluid systems for delivering drugs with poor bioavailability. The NSF funding supports research from June 2022 to May 2023 under the Technology, Innovation, and Partnerships program. This award will allow Superior Nano to advance scientific understanding of surfactant-lipid-water systems and create new knowledge applicable to manufacturing drug nanoparticles using twin-screw extrusion. By...
- Infinifluidics Inc. received a $256,000 National Science Foundation Project Grant under the Engineering (47.041) federal grant program. The grant supports development of on-demand continuous and sterile manufacturing of injectable drug delivery systems at industrial scale on a portable microfluidic chip from July 1, 2021 to June 30, 2022. The Engineering program seeks to improve quality of life and economic strength through innovative engineering research and education. This award will allow...
- This $255,982 National Science Foundation project grant supports the development of sustainable, cost-effective viral clearance membranes by Filtravate, Inc. to enable efficient monoclonal antibody processing. The NSF Technology, Innovation, and Partnerships program seeks technologies leading to breakthrough solutions for national challenges. Specifically, Filtravate will develop a virus filtration membrane using a synthesis process that is more sustainable and affordable than conventional...
- This Project Grant award from the National Science Foundation (NSF) Technology, Innovation, and Partnerships (TIP) program (CFDA 47.084) will develop a novel membrane separation technology to address the energy-efficient separation of small molecules from industrial process streams for a range of industries. The $275,000 award to Avanpore LLC, a for-profit limited liability company located in Woburn, MA, will run from October 1, 2024 to March 31, 2025. The project aims to create functionalized...
- This $274,990 Small Business Innovation Research (SBIR) Phase I award from the National Science Foundation (CFDA 47.084 - NSF Technology, Innovation, and Partnerships) supports the development of a physics-based machine learning platform for predicting the crystal structure of small drug molecules. The technology aims to accelerate and reduce the cost of early-stage pharmaceutical research and development by computationally analyzing the crystal structure properties that determine key...
- The National Science Foundation awarded Diant Pharma Inc. a $256,000 Project Grant under the Engineering (47.041) federal grant program. The grant will support development of an advanced continuous manufacturing system for nucleic acid lipid nanoparticles to improve supply chains for therapeutics and vaccines. Specifically, the small business innovation research Phase I project aims to create a compact, end-to-end manufacturing platform that follows current good manufacturing practices. This...
- The National Science Foundation awarded a $249,884 Project Grant to the Regents of the University of Minnesota under the NSF Technology, Innovation, and Partnerships federal grant program (CFDA 47.084) to develop a decentralized, on-demand production system for large volume parenteral solutions and medical fluids. The University will implement a proof-of-concept prototype capable of producing 100 L/hr of solutions such as electrolyte replacement, intravenous fluids, and dialysis mixtures on-site...
- This National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) Project Grant award of $275,000 to Om Therapeutics Inc. will support the development of a system to enable the rapid, scalable, and cost-effective discovery of new medicines using machine learning. The project aims to encapsulate proteins and small molecules in millions of miniaturized compartments to screen for interactions that could identify novel drug candidates. The key innovations include...
Zaiput Flow Technologies LLC received a $275,000 Project Grant award from the National Science Foundation (NSF) under the NSF Technology, Innovation, and Partnerships program (CFDA 47.084) to develop an innovative, continuous crystallization device for pharmaceutical manufacturing. The goal is to improve the purification process of active pharmaceutical ingredients, which is a critical step used in over 90% of pharmaceutical production. The novel device aims to address scalability, cost, and inconsistency issues with current crystallization approaches to enable faster transitions to continuous manufacturing, facilitate re-shoring of drug production, and reduce drug costs for consumers. The project will first demonstrate the ability to effectively transport slurries and then benchmark the crystallization of a pharmaceutical product against standard batch methods, before scaling up the device for production-scale testing.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $275.0k | 8/8/23 |