The National Science Foundation awarded a $249,884 Project Grant to the Regents of the University of Minnesota under the NSF Technology, Innovation, and Partnerships federal grant program (CFDA 47.084) to develop a decentralized, on-demand production system for large volume parenteral solutions and medical fluids. The University will implement a proof-of-concept prototype capable of producing 100 L/hr of solutions such as electrolyte replacement, intravenous fluids, and dialysis mixtures on-site in hospitals and pharmacies. This will address drug shortages by providing an alternative pharmaceutical supply that ensures resilience without relying on cleanroom manufacturing. The prototype will finalize water treatment, demonstrate full-system feasibility for meeting production rates and stability standards, and validate mixture of a representative dialysis prescription to establish technical feasibility outside of cleanroom facilities. If successful, the system could generate vital medical solutions in disaster, military, or low-resource settings lacking cleanroom infrastructure.