Project Grant R43EY037590
- This federal Project Grant award from the National Eye Institute (NEI), under the Vision Research program (CFDA 93.867), provides funding of $294,662 to Proteris Biotech, Inc. to support research on using the protein Clusterin (CLU) to treat ocular surface disease and dry eye. The project aims to determine whether CLU can protect the ocular surface epithelia from damage and also have an anti-inflammatory effect in dry eye disease. Recombinant human CLU will be tested for efficacy in a mouse...
- The National Eye Institute (NEI), under the U.S. Department of Health and Human Services, awarded a $730,000 Project Grant (CFDA 93.867 - Vision Research) to Human Cell Co, a for-profit biotech firm, to develop an optimized nerve growth factor (NGF) therapy for the treatment of dry eye disease (DED). The funding will support preclinical studies to evaluate the efficacy and mechanism of action of the company's proprietary NGF mutein (HC201) in improving tear film production and corneal...
- This $348,800 Project Grant was awarded on September 30, 2025 by the National Eye Institute (NEI), under the Vision Research federal grant program (CFDA 93.867), to N'Waii Inc. in Chicago, Illinois. The grant supports the development of a first-in-class mitochondrially targeted antioxidant drug candidate for the treatment of dry eye disease (DED), a condition affecting 20% of the global adult population. The drug candidate exhibits potent free radical scavenging capabilities and has demonstrated...
- The National Eye Institute (NEI) has awarded a $356,485 Project Grant to Stellular Bio, Inc. under the NEI's Vision Research federal grant program (CFDA 93.867) to support the scale-up and manufacturing of STLR-201, an off-the-shelf regenerative therapeutic for Sjögren's syndrome-related dry eye disease (SSDE). STLR-201 is a platelet and stem cell-based product that promotes corneal epithelial cell proliferation and improves corneal barrier integrity, addressing the critical unmet need for a...
- The National Eye Institute (NEI) awarded a Project Grant to the Icahn School of Medicine at Mount Sinai for $744,432 on September 1, 2025 under the Vision Research federal grant program (CFDA 93.867). The grant supports a research project titled "Epigenetic Regulation of the Meibomian Gland in Homeostasis and Aging", which aims to delineate epigenetic mechanisms that control meibomian gland function and are dysregulated with aging. The research will investigate the role of histone...
- The National Eye Institute (NEI), under the Department of Health and Human Services, awarded a $358,065 Project Grant to Revel Pharmaceuticals Inc., a biotechnology company in San Francisco, California. The grant is part of the NEI's Vision Research program (CFDA 93.867), which supports research to understand, prevent, and treat vision-related conditions and diseases. The goal of this Phase I grant is for Revel Pharmaceuticals to optimize lead drug candidates and demonstrate the activity of...
- This $257,785 Project Grant was awarded on April 1, 2025 by the National Eye Institute (NEI) under the Vision Research federal grant program (CFDA 93.867). The grant supports the development of a refillable micromachined lens capsule-based drug delivery device for extended intraocular delivery of biologics and immune-modulating peptides to treat non-infectious uveitis. The key products/services to be delivered under this 4-year grant include: Characterizing and controlling the release of the...
- The National Eye Institute (NEI) awarded a $896,046 project grant to The Schepens Eye Research Institute, Inc. in Boston, MA, under the Vision Research federal grant program (CFDA 93.867). The project, titled "Non-Invasive Electrical Stimulation as a Therapy for Diabetic Keratopathy", focuses on exploring the effectiveness of non-invasive transpalpebral electrical stimulation (TPES) as a treatment for diabetic keratopathy, a common complication in individuals with diabetes that results...
- This Project Grant award from the National Eye Institute's Vision Research program provides funding of $442,750 to the University of California, Davis for a research project titled "Defining a New Model of Evaporative Dry Eye Disease." The project aims to utilize an emerging murine model of evaporative dry eye disease, which is characterized by a dysfunctional tear film lipid layer, to better understand the pathogenesis of this condition and explore potential therapeutic approaches....
- The National Eye Institute (NEI) awarded a $482,067 Project Grant to Washington State University (WSU) on August 1, 2025 under the Vision Research federal grant program (CFDA 93.867). The grant supports research to develop novel nanotherapies for the targeted treatment of corneal neovascularization, a sight-threatening condition characterized by the growth of blood vessels into the cornea. The funding will enable WSU researchers to synthesize a unique trehalose-based dendrimer (TRE-D) that...
The National Eye Institute (NEI), under the U.S. Department of Health and Human Services, awarded a $321,904 Project Grant to Proteris Biotech, Inc. through the Vision Research federal grant program (CFDA 93.867). The award, spanning August 1, 2025 to July 31, 2026, will fund the early development of the natural tear protein clusterin (CLU) as a novel approach to treat dry eye disease. The research aims to conduct non-GMP stability analysis of the drug substance and product, as well as perform non-GLP ocular tolerability screening and pharmacokinetic testing. This innovative work builds on the company's prior proof-of-concept data demonstrating CLU's ability to reverse epitheliopathy, reduce inflammation, and restore goblet cell density and corneal nerves in a genetic model of Sjögren's syndrome.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $321.9k | 7/30/25 |