Project Grant R43ES032362

The National Institute of Environmental Health Sciences (NIEHS) awarded Vala Sciences Inc. a $2,434,186 Project Grant under the Environmental Health (CFDA 93.113) federal grant program. The grant is for the development of an assay suite featuring human induced pluripotent stem cell (hiPSC)-derived neurons and support cells to test toxicants and industrial chemicals for potential developmental neurotoxic effects. The project aims to create standardized, high-throughput assays to evaluate...

The Jackson Laboratory was awarded a $718,404 Project Grant (CFDA 93.351 - Research Infrastructure Programs) by the National Institutes of Health to develop a new high-diversity outbred mouse population, the Wild Mouse Diversity Panel (WMDP), as a community resource for mouse genetics research. The project aims to create the WMDP from novel wild-derived inbred mouse strains, generate key genomic resources for the founder strains, and conduct phenotyping and gene mapping studies to demonstrate...

This $457,875 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research to develop a three-dimensional molecular atlas of the developing inferior olivary nucleus (IO) in the mouse brain. The research aims to investigate the molecular heterogeneity of IO neurons and the role of the transcription factor FOXP2 in diversifying both...

This $574,042 federal Project Grant was awarded on June 15, 2024 by the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health (CFDA 93.113) program. The grant supports the development of a high-content in vivo developmental neurotoxicity (DNT) testing platform using the C. elegans model organism. The awardee, Vivoverse, LLC, a woman-owned small business, will establish novel fluorescent reporter strains of C. elegans to monitor neuronal, synaptic, and...

This $500,000 Project Grant from the National Science Foundation's Technology, Innovation, and Partnerships program aims to develop a novel human stem cell-based microfluidic developmental toxicology platform. The University of Michigan will receive funding from September 2022 to August 2024 to conduct technological development of a repeatable, controllable, high-throughput microfluidic system for generating three-dimensional multicellular organoid models for toxicity testing. The platform seeks...

This Project Grant award from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health (CFDA 93.113) program provides $421,047 to the University of Toledo to conduct a research study on the interaction between genetic and environmental risk factors for autism and other neurodevelopmental disorders. The key objectives are to examine how developmental exposure to the pyrethroid pesticide deltamethrin interacts with the Shank3 gene mutation in a prairie vole...

This Project Grant award from the National Institutes of Health (NIH) Office of the Director under the Research Infrastructure Programs (CFDA 93.351) provides $240,039 to Baylor College of Medicine to develop a novel mouse model for detecting genome editing events. The project aims to create an alternative "single-hit" strategy using CRISPR/Cas9 editing to activate a fluorescent reporter system in the existing AI9 transgenic mouse line. This new approach is expected to be more...

This Project Grant award from the National Institutes of Health (NIH) under the Research Infrastructure Programs (CFDA 93.351) provides $236,250 to the University of Rhode Island (URI) to develop and validate a novel knock-in inducible mitochondrial DNA (mtDNA) mutator mouse model. The goal is to use this mouse model to study the role of mitochondrial dysfunction in a broad range of human diseases, including non-communicable diseases, neurological disorders, and age-related conditions. The award...

This Project Grant award from the National Institute of Environmental Health Sciences (NIEHS), under the Environmental Health (CFDA 93.113) federal grant program, supports the development of a comprehensive hen's egg model for genotoxicity testing. The $295,734 award to Litron Laboratories LTD, a for-profit biotechnology company, will be used to create an in vitro assay that leverages the hen's egg's endogenous metabolic activity and organ systems to simultaneously evaluate genotoxicity in blood...

The federal Project Grant award R24OD038114, totaling $775,888.00, was provided by the National Institutes of Health (NIH) under the Research Infrastructure Programs (CFDA 93.351). The grant will support the development and validation of a novel, modular CRISPR-ready HLA transgenic mouse platform at the La Jolla Institute for Immunology. This platform will allow researchers to rapidly generate HLA class I and II transgenic mouse models expressing specific HLA alleles relevant to a broad range of...