Project Grant R43ES019824

This Project Grant award from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health federal grant program (CFDA 93.113) provides $306,872 to Bioprinting Laboratories Inc. to establish a high-throughput screening platform using genetically engineered induced pluripotent stem cells (iPSCs) and brain organoids to assess the developmental neurotoxicity (DNT) potential of chemicals. The key products and services to be delivered include: Development of an...

This $500,000 Project Grant from the National Science Foundation's Technology, Innovation, and Partnerships program aims to develop a novel human stem cell-based microfluidic developmental toxicology platform. The University of Michigan will receive funding from September 2022 to August 2024 to conduct technological development of a repeatable, controllable, high-throughput microfluidic system for generating three-dimensional multicellular organoid models for toxicity testing. The platform seeks...

This $521,992 Project Grant award from the National Institute of Environmental Health Sciences (CFDA 93.113 - Environmental Health) is funding research at Midwestern University to examine how exposure to phthalates, common plasticizers, can impact reproductive health and germ cell development. The project has two key objectives: 1) Elucidate how phthalates may disrupt germ cell development by impacting LRH1-mediated regulation of steroidogenesis and metabolism in mouse Sertoli cells, and 2)...

This $169,500 Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), supports research by New York University (NYU) School of Medicine to characterize soma-germline interactions during adult spermatogenesis. The research aims to determine how a secreted, conserved, immunoglobulin (Ig) domain protein maintains the blood-testis barrier in somatic support cells of the...

This federal Project Grant award of $606,518, provided by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), supports research on spermatogonial stem cell (SSC) transplantation and culture for cancer patients who have experienced fertility loss due to medical treatments. The key products or services to be delivered through this 5-year project (6/5/2025 - 5/31/2030)...

This Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) provides $248,999.00 in funding to Colorado State University (CSU) for research on the mechanisms of temperature-sensitive meiotic chromosome structures in male infertility. The research aims to exploit the model organism Caenorhabditis elegans to investigate how sexual dimorphisms in the...

The National Institute of Child Health and Human Development (NICHD) awarded a $613,556 Project Grant under the Child Health and Human Development Extramural Research program (CFDA 93.865) to Orygyn Medical Devices, LLC. The grant supports the development of a novel Tubal Selective Delivery System (TSDS) designed to safely and selectively administer fluids, foams, or gels to the fallopian tubes through a nonsurgical transcervical approach. The objectives of this Phase I project are to 1) compare...

This Project Grant award of $419,014 from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), supports research at the University of Kentucky Research Foundation investigating the role of the SOX9 transcription factor in regulating the ovulatory process and corpus luteum development in the human ovary. The research aims to advance understanding of the mechanisms underlying ovarian...

This $724,714 Project Grant was awarded on May 5, 2025 by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The project aims to evaluate the effects of exogenous anti-Müllerian hormone (AMH) on ovarian function and fertility in non-human primates as a model for understanding its potential applications in human reproductive health. The key products and services to be...

This federal Project Grant award of $128,898 from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) supports research into how the 3D structure of the genome regulates gene expression during male germ cell development and spermatogenesis. The research aims to elucidate how the 3D chromatin structure and CTCF-mediated genome organization in male germ cells establishes...