Project Grant R01HD114856
Award Date
6/5/25
Completion Date
5/31/30
Dollars Obligated
$607K
Federal Agency
National Institute of Child Health and Human Development
Federal Grant Program
93.865
Assistance Type
Project Grant
Place of Performance
Pennsylvania, USA
Similar Awards
This Project Grant award from the National Institute of Child Health and Human Development (CFDA 93.865 - Child Health and Human Development Extramural Research) provides $107,458 to Duke University to study the mechanisms of double-strand break repair in fetal male germ cells. The research aims to determine how male germ cells, which are precursors to spermatogonial stem cells, respond to and repair DNA double-strand breaks during a critical period of cellular quiescence prior to birth. The...
This federal Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the CFDA 93.865 Child Health and Human Development Extramural Research program, provides $192,056 to support research on using adeno-associated virus (AAV) gene therapy to restore fertility in male infertility models with Sertoli cell dysfunction. The primary goal is to demonstrate the feasibility and safety of in vivo Sertoli cell gene therapy to restore spermatogenesis without...
This Project Grant award, worth $271,728, was issued by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The funding supports research conducted by the Whitehead Institute for Biomedical Research in Cambridge, Massachusetts, to uncover the molecular mechanisms that initiate and maintain germ cell identity. The primary goals of the research project are to: (A) discover the mechanisms that...
This Project Grant award, totaling $658,633, was provided by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) to support research into the mechanisms of the MEIG1 protein complex in mammalian spermiogenesis and fertilization. The research aims to explore how the MEIG1 complex plays a role in transporting cargo proteins for sperm flagella assembly and in remodeling chromatin during the final...
This Project Grant award of $231,413 from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) supports research to establish in vitro models reconstituting human testicular germ cell neoplasia in situ (GCNIS), which are precursors to testicular cancers (TCs). The recipient, The General Hospital Corporation (doing business as Massachusetts General Hospital), will generate human induced pluripotent stem cell-derived primordial germ cell-like cells (iPSC-PGCLCs) and genetically...
The National Institute of Child Health and Human Development (NICHD) awarded a $413,843 Project Grant (CFDA 93.865 - Child Health and Human Development Extramural Research) to The Pennsylvania State University, doing business as Penn State, to develop advanced biofabricated seminiferous tubules for in vitro spermatogenesis research. The proposed work aims to use micro-extrusion technology to precisely fabricate microtubes that mimic the cellular composition and organization of in vivo...
This $225,306 Project Grant award from the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) supports a collaborative research project between researchers at the University of Southern California (USC) and a German partner to investigate the long-term impact of early-life growth signals on adult hematopoietic (blood) stem cell function and selection. The key products and services to be delivered under this 3-year award include: 1) using stem cell transplantation and...
This $453,000 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports research to define the molecular mechanisms and cellular dynamics required to assemble a functional stem cell niche during embryonic development. The research, conducted at East Carolina University, aims to elucidate the signaling pathways, transcriptional regulators, and cytoskeletal processes that guide the migration and...
This $169,500 Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), supports research by New York University (NYU) School of Medicine to characterize soma-germline interactions during adult spermatogenesis. The research aims to determine how a secreted, conserved, immunoglobulin (Ig) domain protein maintains the blood-testis barrier in somatic support cells of the...
This $1,216,126 federal Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), supports research at Washington State University to investigate the role of RUNX transcription factors in balancing germ cell fate towards proliferation/self-renewal or differentiation in the male germline. The project aims to elucidate the mechanisms by which the RUNX family coordinates this...