Project Grant R43DK142739
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded The Broad Institute, Inc. $1,647,485 on September 19, 2025, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to conduct massive-scale genomic risk assessment across monogenic and common forms of diabetes. The award will support analysis of the largest dataset of rare variation linked to diabetes phenotyping, comprising more than 1.1 million participants (33 percent...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded The Children's Hospital of Philadelphia $695,683 on August 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to develop improved stem cell-derived beta cells for cellular therapeutics of diabetes. The project, titled "Making a Better Beta Cell for Cellular Therapeutics of Diabetes," focuses on engineering human pluripotent stem cell-derived beta cells capable...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded $178,000 to Beckman Research Institute of The City of Hope on May 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate how the native pancreatic microenvironment regulates human islet cell function in health and type 1 diabetes. The research employs human pancreatic tissue slices to preserve native cellular architecture and directly compares hormone...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded a $802,595 cooperative agreement to Pacific Northwest National Laboratory, a division of Battelle Memorial Institute, on May 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The recipient will conduct spatial multi-omics profiling of human pancreatic islet microenvironments to discover pathways and molecular mediators of early Type 1 Diabetes pathogenesis. The...
- The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), an institute of the Department of Health and Human Services National Institutes of Health, awarded $795,620 to the University of Massachusetts Medical School on July 15, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The award funds development and validation of gene-editing technologies to engineer stem cell-derived islets for type 1 diabetes treatment. The research...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded The Leland Stanford Junior University $782,886 on February 18, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to support research on obesity control through an appetite-suppressing peptide. The research addresses the urgent need for new metabolies, including obesity and associated metabolic disorders. Work is performed in Palo Alto, California with a period of...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Beckman Research Institute of the City of Hope $307,108 on September 15, 2025, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to conduct basic research on alpha cell heterogeneity in Type 1 Diabetes. The funded research will investigate functional heterogeneity within pancreatic alpha cell subpopulations and their regulatory interactions with neighboring beta and delta cells...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded The University of Texas Southwestern Medical Center $799,693 on June 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847, Project Grant R01DK147004). The recipient will develop bioengineered pancreatic islet beta cells as a replacement therapy for Type 1 Diabetes. The research optimizes immune-checkpoint-engineered beta cells designed to induce long-term transplant...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Emory University $1,574,634 on September 18, 2025, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to develop clinical and genetic data frameworks informing precision health policy design for GLP-1 receptor agonist (GLP-1RA) coverage. The recipient will develop an agent-based microsimulation model for obesity-related cardiometabolic complications; create predictive models...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Emory University $824,296 on February 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to identify novel type 2 diabetes phenotypes and assess their association with diabetes complications through longitudinal analysis of clinical data and polygenic risk scores. The research leverages the Kaiser Permanente Research Bank cohort, a nationally representative dataset...
The National Institute of Diabetes and Digestive and Kidney Diseases awarded Delphi Stem, Inc. $306,863 on August 15, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to develop a framework for evaluating type 2 diabetes medication efficacy using patient-derived cellular models. The recipient will generate personalized islet-like aggregates from patient cells to predict drug responsiveness and tailor treatment regimens, with the goal of improving diabetes care and reducing health and economic burdens in economically vulnerable populations. The research addresses systemic barriers such as limited access to preventive care, delayed diagnoses, and insulin unaffordability that disproportionately impact disadvantaged communities. Performance takes place in Atlanta, Georgia, with a period of performance through July 31, 2027. The award is classified as a Project Grant, an assistance type supporting extramural basic and clinical biomedical research that improves understanding of disease mechanisms and leads to improved prevention, diagnosis, and treatment of diabetes and related conditions.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $306.9k | 8/13/26 |