Federal Grant Award Summary

Emory University received a $824,296 Project Grant from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), awarded February 1, 2026, with completion targeted for December 31, 2030. The award supports the "Putting Phenotypes and Polygenics Into Practice for Diabetes Care (4PDC)" research initiative, which will deliver comprehensive research services aimed at addressing Type 2 Diabetes (T2D) heterogeneity through advanced phenotypic classification and genomic analysis.

The project will produce evidence-based research products including novel T2D phenotypes derived from widely available clinical variables sourced from approximately 110,434 individuals across eight U.S. states within the Kaiser Permanente Research Bank cohort. Through longitudinal assessment over a 13-year mean follow-up period, the research will deliver insights into T2D phenotype dynamics, disease progression related to aging, and associations with T2D complications. The study will employ advanced data-driven clustering techniques and integrate polygenic risk score analysis to advance understanding of biological mechanisms driving heterogeneous T2D presentations, with particular focus on improving generalizability across diverse populations and capturing dynamic changes in disease phenotypes over time.