Project Grant R01DK147680
- Federal Grant Award Summary The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded the University of Pennsylvania a $787,367 Project Grant on September 9, 2025, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to map the gene regulatory architecture of pancreatic islet-specific cell types in relation to diabetes. The project, scheduled for completion by June 30, 2030, will create the largest integrated map of islet cell...
- Federal Project Grant Award Summary The University of California, San Francisco (UCSF) was awarded $3,140,632 by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) for a four-year project period from September 1, 2025, through August 31, 2029. This Project Grant supports fundamental biomedical research focused on elucidating the mechanisms of human endocrine lineage commitment...
- Federal Grant Award Summary The Leland Stanford Junior University received a $724,180 Project Grant awarded September 1, 2025, by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). This five-year research project, extending through August 31, 2030, focuses on facilitating islet implantation and engraftment following transplantation through the development of primed umbilical...
- Federal Grant Award Summary The Scripps Research Institute received a $1.6 million Project Grant from the National Institute of Diabetes and Digestive and Kidney Diseases under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), awarded August 15, 2025, with completion targeted for June 30, 2029. The research initiative focuses on elucidating the initiation of anti-islet autoimmunity and the regulation of major histocompatibility complex (MHC) Class II...
- Federal Project Grant Summary Cornell University received a $509,265 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), effective September 25, 2025, with completion scheduled for July 31, 2029. The award funds development of an immunomodulatory and vascularized cell delivery device designed to enable safe, long-term insulin-producing islet cell...
- Federal Grant Award Summary The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded $761,577 to Massachusetts General Hospital (The General Hospital Corporation) on March 15, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The award extends through January 31, 2030, and funds fundamental research interrogating the roles of histone methylation marks—H3K4 methylation (H3K4me) and H3K27 methylation (H3K27me)—in...
- Federal Project Grant Award Summary The University of Minnesota, through its Office of Sponsored Projects Administration, received a $4.5 million Project Grant from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The award, effective September 5, 2025, through August 31, 2028, funds research to develop engineered regulatory T cells (Tregs) as a therapeutic intervention for...
- Federal Grant Award Summary Boston University Medical Campus received a $100,228 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), effective February 1, 2027, with a completion date of June 30, 2029. The award funds research to develop and evaluate induced pluripotent stem cell (iPSC)-derived endothelial cell therapy as a therapeutic intervention to...
- Federal Grant Award Summary The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a Project Grant of $248,975 to University of Colorado-Denver under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) on May 15, 2026, with final completion scheduled for April 30, 2029. The research project investigates pancreatic beta-cell glucose toxicity and messenger RNA (mRNA) translation dysfunction in the context of type 1 diabetes...
- Federal Project Grant Award Summary The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $2,390,830 Project Grant to the University of California, San Francisco (UCSF) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) effective September 1, 2025, through August 31, 2029. This award funds the development of scalable and transplantable pancreatic islet organoids with engineered oxygenation to improve therapeutic...
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded University of Massachusetts Medical School a $795,620 Project Grant (CFDA 93.847: Diabetes, Digestive, and Kidney Diseases Extramural Research) on July 15, 2026, to develop somatic cell gene editing (SCGE) technologies for improving stem cell-derived islet transplantation outcomes in Type 1 Diabetes treatment. The research, titled "Gene Editing for Environmentally-Responsive, Immune-Evasive Stem Cell-Derived Islets," leverages prime editing, integrase-mediated DNA insertion, and machine learning-designed cis-regulatory elements to engineer human-induced pluripotent stem cell (hiPSC) lines with real-time molecular reporters and stimulus-responsive genetic rewiring capabilities. This multidisciplinary approach aims to endow stem cell-derived islets with graft context-based immune evasion while enabling non-invasive monitoring of inflammation, viability, and functional mass. The project, with a completion date of May 31, 2031, focuses on two primary research aims: (1) engineering molecular reporters in hiPSC lines to quantify B cell biomass, stress, apoptosis, and inflammation through site-specific genetic integration, with validation conducted in vitro and in vivo using humanized NSG MHC-DKO mice in the context of allorejection; and (2) rewiring regulatory elements to achieve the immune-evasive and environmentally-responsive characteristics necessary for successful long-term transplantation. The research team comprises multidisciplinary experts in Type 1 Diabetes biology, stem cell models, genome engineering technologies, and computational genomics.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $795.6k | 7/10/26 |