This National Science Foundation Project Grant of $255,757 awarded on August 15, 2022 will fund the development of an ultrasound-based point-of-care periodontal imaging device under the NSF Technology, Innovation, and Partnerships program (CFDA 47.084). Stylosonic LLC will develop an integrated device for acoustic imaging of the entire mouth that automatically processes imaging data to assist dentists in assessing gingival health and periodontitis. Key objectives include miniaturizing imaging...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $148,569 Project Grant under the Oral Diseases and Disorders Research program (CFDA 93.121) to the Regents of the University of Michigan. The goal of this 3.5-year research project is to develop novel ultrasound-based quantitative biomarkers and a machine learning classifier to improve diagnosis and monitoring of periodontal inflammation. The research will involve comprehensive quantitative ultrasound analysis,...
This Project Grant award, with a total funding amount of $1,705,144.00, was provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121). The award's objective is to develop novel therapies that can endogenously stimulate periodontal regeneration, circumventing the need for transplantation of biomaterials or osteogenic tissue. The research aims to 1) identify specific cell surface markers to isolate and...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), supports the development of a biomaterial-enhanced system for targeted delivery of engineered microbes that secrete the anti-inflammatory cytokine interleukin-10 (IL-10) to treat experimental periodontitis. The total award amount is $873,546.00 with a project period from September 4, 2024 to September 3, 2026. The goal of this...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research Federal Grant Program (CFDA 93.121) provides $196,875 to the University of California, Los Angeles (UCLA) to investigate the role of salivary PIWI-interacting RNAs (piRNAs) in oral wound healing. The overarching goal is to characterize how these novel oral piRNAs may accelerate human oral keratinocyte proliferation and migration, which could lead to...
The University of Tennessee (UT) has been awarded a $423,500 Project Grant from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121). The grant will fund the development and evaluation of a personalized bioprinting technology for de novo regeneration of the periodontal ligament (PDL) in avulsed (knocked out) permanent teeth. The key products and services to be delivered under this grant include: Optimization of...
This Project Grant award, provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), will support the development of a bio-inspired scaffold (referred to as "PerioPatch") for regenerating Sharpey's fibers and periodontal tissues. The $588,952 award, effective April 18, 2025 through March 31, 2030, aims to integrate crucial biophysical and biochemical cues into a matrix to guide periodontal...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides funding of $294,632 to Greenmark Biomedical Inc. for the development of an intraoral camera system. The project aims to create a minimally viable product that can collect clinical white-light and fluorescent images of dental caries illuminated by a fluorescent biopolymer mouth rinse. The collected images will be...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research Federal Grant Program (CFDA 93.121), provides $923,623 to Virtici LLC to advance the development of a first-in-class, cyclic peptide (VTC-880) for the treatment and prevention of gingivitis and periodontitis. The key objectives are to manufacture the peptide, establish potency and analytical assays, determine the optimal formulation and in vitro...
This $304,019 Project Grant awarded by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research Federal Grant Program (CFDA 93.121) aims to develop a novel antibody-based therapy to prevent alveolar bone loss in severe periodontitis. The funding will support the identification and evaluation of a panel of human anti-human OC-STAMP monoclonal antibodies, with the goal of selecting a lead candidate to be tested in a ligature-induced...