This federal Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA), under the Alcohol Research Programs (CFDA 93.273) federal grant program, will provide $701,135 to Yale University to characterize brain and peripheral cortisol dysregulation in individuals with alcohol use disorder (AUD). The project aims to fully describe the availability of the enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1), which regulates cortisol levels in the brain, and to...
The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded a $1,373,036 Project Grant under the Alcohol Research Programs (CFDA 93.273) to Yale University. The overarching goal of this 5-year research project (Sep 2024 - Aug 2029) is to enhance the understanding and prediction of heavy drinking episodes during initial recovery from alcohol use disorder (AUD). The project aims to leverage wearable biosensor technology and artificial intelligence to develop real-time predictive...
This federal Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA), under the Alcohol Research Programs (CFDA 93.273) federal grant program, will support the development of novel 3D human brain circuits to investigate the role of microglia in alcohol use disorder (AUD) and Alzheimer's disease (AD) pathology. The $223,531 award to the University of North Carolina at Chapel Hill will fund research to elucidate how alcohol-induced changes in microglial metabolism...
This Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA), under CFDA Program 93.273 - Alcohol Research Programs, will support research on avoidance learning and pain circuit dysfunction in alcohol use disorders (AUD). The $497,581.76 award, effective September 10, 2024, will enable the principal investigator at Yale University to collect functional MRI data from treatment-seeking AUD patients during a probabilistic learning task involving pain and reward....
This $711,808 Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) will support a multi-year research project at Yale University to investigate the neural mechanisms underlying the stress response and its relationship to chronic alcohol consumption. The key objectives of the research are to: 1) develop a connectome-based model to predict stress responses using functional MRI data, 2) characterize dynamic...
This federal Project Grant award of $1,135,243 from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) will support research to investigate changes in neural mechanisms associated with cognitive reappraisal and alcohol cue reactivity during early abstinence from alcohol use disorder (AUD) treatment. The research, conducted by the University of Colorado-Denver and involving sub-awards to Emory University and the University of Denver,...
This federal Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA), under CFDA Program 93.273 Alcohol Research Programs, provides $148,568 to the University of California, Los Angeles (UCLA) to conduct research on the neuroepigenetic mechanisms underlying the transgenerational effects of alcohol exposure. The key objectives of this research project are to: Identify the neuronal epigenetic changes, particularly histone acetylation patterns, that accompany alcohol...
This $366,406 Project Grant was awarded by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) to Yale University. The grant will be used to develop two novel human laboratory models to screen potential medications for Alcohol Use Disorder (AUD). The first model will assess a medication's ability to increase abstinence and reduce heavy drinking, which align with key FDA endpoints for AUD medication approval. The second model will...
This Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA), under the Alcohol Research Programs (CFDA 93.273), provides $423,313 to Biosymetrics Inc. to develop an AI-driven in vivo profiling platform in zebrafish for identifying potential therapeutics for alcohol use disorder (AUD). The project aims to leverage Biosymetrics' existing AI-based zebrafish screening capabilities and experimental findings on AUD to create a commercial platform for accelerated AUD...
The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded a $1,547,718 Project Grant under the Alcohol Research Programs (CFDA 93.273) to the University of Kansas Medical Center Research Institute, Inc. (KUMCRI) from September 1, 2024 to May 31, 2029. The project will investigate the role of KDM5 demethylases in regulating cell-cell communication in the development and resolution of alcohol-associated liver disease. Specifically, the research aims to determine how KDM5B and KDM5C...