Project Grant R34AA031678
Award Date
9/1/24
Completion Date
8/31/26
Dollars Obligated
$366K
Federal Agency
National Institute on Alcohol Abuse and Alcoholism
Awardee
Yale Univ (FL6GV84CKN57)
Federal Grant Program
93.273
Assistance Type
Project Grant
Place of Performance
New Haven, CT 06510, USA
Similar Awards
The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded a $1,373,036 Project Grant under the Alcohol Research Programs (CFDA 93.273) to Yale University. The overarching goal of this 5-year research project (Sep 2024 - Aug 2029) is to enhance the understanding and prediction of heavy drinking episodes during initial recovery from alcohol use disorder (AUD). The project aims to leverage wearable biosensor technology and artificial intelligence to develop real-time predictive...
The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded a $481,428 Project Grant under the Alcohol Research Programs (CFDA 93.273) to the Moses-Weitzman Health System, Inc. on September 20, 2024. The project, titled "Translating Research into Practice on Alcohol and Polysubstance Use Disorders by Educating the Interprofessional Primary Care Team," aims to improve the capacity of primary care providers in federally qualified health centers and other safety net settings to...
This $499,987 Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) will fund the development of a High Throughput Alcohol Screening Platform (HT-ASP) that incorporates cortical organoids. The project aims to create an automated platform to mature, maintain, and assay over 100 organoids in culture, providing a robust and genetically diverse system for screening potential alcohol use disorder therapeutics. The...
This Project Grant award of $594,784 from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) will fund a postmortem, multi-omic study of brains from 341 total subjects to identify novel lasting transcriptomic and epigenetic changes in biological pathways that may serve as biomarkers and therapeutic targets for alcohol use disorder (AUD). The research will analyze RNA sequencing and whole-genome bisulfite sequencing data across 8 brain...
This federal Project Grant award of $581,869 from the National Institute on Alcohol Abuse and Alcoholism (NIAAA), under the CFDA 93.273 Alcohol Research Programs, will fund a human neuroscience study to investigate the role of glucocorticoid receptor (GR) antagonism in alcohol use disorder (AUD). The study will evaluate the effects of a selective GR antagonist, PT150, on behavioral, neuroendocrinological, and physiological responses to stress and alcohol in 34 participants. The research aims...
This $673,500 Project Grant from the National Institutes of Health's National Institute on Alcohol Abuse and Alcoholism will fund Amygdala Neurosciences, Inc. to develop new, potent, selective, and reversible inhibitors of aldehyde dehydrogenase 2 (ALDH2) for the treatment of alcohol use disorder. The goal is to implement an innovative screening technology to discover novel compounds that reduce craving and alcohol consumption by selectively inhibiting ALDH2 in a reversible manner, avoiding...
This Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA), under the Alcohol Research Programs (CFDA 93.273), provides $423,313 to Biosymetrics Inc. to develop an AI-driven in vivo profiling platform in zebrafish for identifying potential therapeutics for alcohol use disorder (AUD). The project aims to leverage Biosymetrics' existing AI-based zebrafish screening capabilities and experimental findings on AUD to create a commercial platform for accelerated AUD...
This Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA), under CFDA Program 93.273 - Alcohol Research Programs, will support research on avoidance learning and pain circuit dysfunction in alcohol use disorders (AUD). The $497,581.76 award, effective September 10, 2024, will enable the principal investigator at Yale University to collect functional MRI data from treatment-seeking AUD patients during a probabilistic learning task involving pain and reward....
This federal Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA), under the Alcohol Research Programs (CFDA 93.273) federal grant program, will provide $701,135 to Yale University to characterize brain and peripheral cortisol dysregulation in individuals with alcohol use disorder (AUD). The project aims to fully describe the availability of the enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1), which regulates cortisol levels in the brain, and to...
The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded a $330,829 Project Grant under the Alcohol Research Programs (CFDA 93.273) to the Board of Regents of the University of Nebraska, University of Nebraska Medical Center (UNMC) Division. The grant, titled "Leveraging Alcohol Use Disorder Screening for Treatment in Routine Perioperative Care: ALLUSCARE", aims to leverage existing electronic health record-integrated alcohol screening tools to increase the provision of...