The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded a Project Grant under the Alcohol Research Programs (CFDA 93.273) to The Johns Hopkins University in the amount of $807,050 on August 20, 2024. The grant will fund a research project examining the neural circuit effects of chronic alcohol use on cognition and behavior in rodent models. The key objectives are to: 1) Characterize changes in neural activity within the anterior cingulate cortex, orbitofrontal cortex, and...
The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded a $119,253 Project Grant under the Alcohol Research Programs (CFDA 93.273) to the University of New Mexico Health Sciences Center. The grant will fund research to investigate the impact of third trimester alcohol exposure on sharp-wave ripples, a key neural mechanism for learning and memory, in the hippocampal-retrosplenial cortex circuit. The project will utilize a mouse model, in vivo electrophysiology, and optogenetics...
This federal Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA), under the Alcohol Research Programs (CFDA 93.273) federal grant program, will support the development of novel 3D human brain circuits to investigate the role of microglia in alcohol use disorder (AUD) and Alzheimer's disease (AD) pathology. The $223,531 award to the University of North Carolina at Chapel Hill will fund research to elucidate how alcohol-induced changes in microglial metabolism...
The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded a $143,784 Project Grant (CFDA 93.273 - Alcohol Research Programs) to Louisiana State University Health Sciences Center New Orleans on July 30, 2024. The grant will support research to investigate the effects of adolescent opioid exposure on alcohol-induced hyperalgesia (increased pain sensitivity) in adult mice. The research aims to test the hypothesis that exposure to opioids during adolescence increases the magnitude of...
This federal Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA), under the Alcohol Research Programs (CFDA 93.273), provides $657,000 to Louisiana State University Health Sciences Center-Shreveport to investigate the role of lysophosphatidic acid (LPA) signaling in alcohol-induced blood-brain barrier disruption and neuroinflammation. The key objectives are to assess the effects of heavy alcohol consumption on mitochondrial function and redox balance, evaluate...
The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded a $537,587 Project Grant under the Alcohol Research Programs (CFDA 93.273) to The University of Texas Southwestern Medical Center to conduct research on the metabolic consequences of liver inflammation on alcohol consumption and alcohol-associated liver disease (ALD). The key objectives are to identify the mechanisms by which the transcription factor IRF3 suppresses the expression and secretion of the metabolic regulator...
This Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA), under the Alcohol Research Programs (CFDA 93.273) federal grant program, will support the development and testing of a novel in vivo model called CHIMERA-BONCAT. This model will enable comprehensive, unbiased, and cell-type-specific characterization of the human microglial response to alcohol exposure. The $214,385 award, with a period of performance from August 2024 to July 2026, will fund research...
The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded a $128,481 Project Grant under the Alcohol Research Programs (CFDA 93.273) to the University of New Mexico Health Sciences Center (UNM HSC) to investigate potential therapeutic interventions to restore hippocampal neurogenesis in a mouse model of fetal alcohol spectrum disorder (FASD). The 3-year project aims to determine if pharmacological, genetic, or activity-based approaches can reinstate the neurogenic response to...
The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded a $1,547,718 Project Grant under the Alcohol Research Programs (CFDA 93.273) to the University of Kansas Medical Center Research Institute, Inc. (KUMCRI) from September 1, 2024 to May 31, 2029. The project will investigate the role of KDM5 demethylases in regulating cell-cell communication in the development and resolution of alcohol-associated liver disease. Specifically, the research aims to determine how KDM5B and KDM5C...
The National Institute on Alcohol Abuse and Alcoholism (NIAAA) has awarded a $152,000 Project Grant under the Alcohol Research Programs (CFDA 93.273) to Des Moines University Osteopathic Medical Center (DMU) to study the role of GLUD1 receptors in regulating structural plasticity during chronic ethanol exposure and withdrawal. The two-year grant, awarded on September 1, 2023, will support DMU's research aimed at understanding how GLUD1 receptor function and expression influence dendritic spine...