The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded a $119,600 Project Grant under the Alcohol Research Programs (CFDA 93.273) to the University of Kansas Medical Center Research Institute, Inc. (KUMCRI) with a performance period from July 2024 to July 2027. The grant funds research to identify and understand the mechanisms by which aging and alcohol consumption cooperatively contribute to the development of alcohol-associated liver disease (ALD). The project aims to...
This $537,587 federal Project Grant award, provided by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273), supports research to identify the mechanisms by which the interferon regulatory factor 3 (IRF3) suppresses the expression and secretion of fibroblast growth factor 21 (FGF21) in the liver, and to understand the impact of this regulatory axis on alcohol consumption and alcohol-associated liver disease (ALD). The grant, which...
This Project Grant award, valued at $1,158,934.00, was issued on August 20, 2024 by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) federal grant program. The award supports research to understand the mechanisms of mitochondrial dynamics, quality control, and mitochondrial DNA-mediated inflammation in alcohol-associated liver disease. The University of Kansas Medical Center Research Institute, Inc. (KUMCRI) is the prime recipient...
This $1,547,718 federal Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) will fund research to investigate the role of histone demethylases KDM5B and KDM5C in alcohol-associated liver disease development and resolution. The research, conducted by the University of Kansas Medical Center Research Institute, Inc. (KUMCRI), aims to determine how these epigenetic regulators in hepatocytes influence cell-cell...
The University of Colorado-Denver has been awarded a $179,154 Project Grant from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) grant program. The funding will support research to elucidate the role of Wnt ligands and related signaling pathways in driving the activation of hepatic stellate cells, which are key mediators of liver fibrosis in alcohol-related liver disease. The 2-year project aims to characterize the impact of...
This federal Project Grant award for $153,694, provided by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) federal grant program, supports research to model a national graduated-BAC per se policy for 21-24 year old drivers to reduce alcohol-impaired driving injury and fatal crashes. The primary awardee, the University of California, Irvine, will lead this research effort, which includes a sub-award to Colorado State University to...
This Project Grant award, totaling $213,000.00, was provided by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) federal grant program. The goal of this 24-month project, with a period of performance from August 22, 2024 to July 31, 2026, is to assess the role of nitric oxide synthase 2 (NOS2) and the interleukin-22 (IL-22)-STAT3 signaling pathway in alcohol-mediated exacerbation of ulcerative colitis (UC) pathology. The research...
This $349,738 project grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) is funding research at Ursinus College to investigate the role of microglial fractalkine signaling in altered dopaminergic wiring resulting from fetal alcohol spectrum disorders (FASD). The research aims to (1) define the developmental timing of alcohol-induced alterations in fractalkine signaling, and (2) determine the impact of these changes on...
This Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA), under the Alcohol Research Programs (CFDA 93.273) federal grant program, will fund a translational genetic analysis study to identify the genomic architecture of alcohol sensitivity and tolerance in both humans and mice. The $574,808 award, granted on Sep 9, 2024, will support the following key activities: Conducting genome-wide association studies (GWAS) of alcohol sensitivity and tolerance in European...
The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded a $438,375 Project Grant under the Alcohol Research Programs (CFDA 93.273) to Cedars-Sinai Medical Center to establish a human liver-on-a-chip model for studying alcohol-associated liver disease (ALD). The 2-year project, starting September 2023, aims to investigate the roles of liver sinusoidal endothelial cells and acetaldehyde metabolism in regulating ethanol-induced liver damage as well as the contribution of fibrotic...