Project Grant R43AA031448

Award Date 6/1/24
Completion Date 5/31/25
Dollars Obligated $274K
Federal Grant Program
93.273
Assistance Type
Project Grant
Place of Performance
Georgia, USA
Similar Awards
This federal Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA), under the Alcohol Research Programs (CFDA 93.273) federal grant program, is providing $399,293 to Echelon Biosciences Inc. to demonstrate the feasibility of a rapid point-of-care phosphatidylethanol (PEth) lateral flow immunoassay (POC-LFI). The goal is to develop a prototype POC-LFI device that can detect PEth, a long-term alcohol biomarker, at concentrations suitable for abstinence...
This federal Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) will support research to investigate the impact of alcohol consumption on RNA modifications and their role in the development and progression of alcohol-associated liver disease (ALD). The total funding amount is $374,598, with a performance period from August 15, 2024, to July 31, 2026. The key objectives of this research project are to 1) map...
This Project Grant award of $523,477.00 from the National Institute on Alcohol Abuse and Alcoholism (NIAAA), under the Alcohol Research Programs (CFDA 93.273) federal grant program, supports a research study conducted by the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University. The study aims to develop a human-relevant in vitro liver culture model to investigate the mechanisms underlying alcohol-associated liver disease (ALD) and its interaction with the rs738409...
The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded a $438,375 Project Grant under the Alcohol Research Programs (CFDA 93.273) to Cedars-Sinai Medical Center to establish a human liver-on-a-chip model for studying alcohol-associated liver disease (ALD). The 2-year project, starting September 2023, aims to investigate the roles of liver sinusoidal endothelial cells and acetaldehyde metabolism in regulating ethanol-induced liver damage as well as the contribution of fibrotic...
This Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) provides $386,196 to the University of Kansas Medical Center Research Institute, Inc. (KUMCRI) to conduct research on the mechanisms of mitochondrial dynamics, quality control, and mitochondrial DNA-mediated inflammation in alcohol-associated liver disease. The study aims to understand how chronically accumulated "megamitochondria" in the...
This federal Project Grant award, funded by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273), supports research to elucidate the mechanism and significance of translatome alteration as a critical pathophysiology of alcoholic fatty liver (AFL). The $238,445 grant, with a project period from May 2024 to April 2026, will be conducted by the University of Southern California. The research aims to determine the molecular mechanism of...
This federal Project Grant award, funded by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273), aims to define the contributions of the MIF-CD74 signaling pathway in alcohol-associated liver disease (ALD). The $442,898 award to the University of Texas Health Science Center at Houston will support research activities over a 5-year period from September 1, 2024 to July 31, 2029. The key objectives are to: 1) characterize the role of...
This Project Grant award of $594,784 from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) will fund a multi-omic study to investigate the molecular pathology of alcohol use disorder (AUD). The project, led by Yale University, aims to identify novel transcriptomic and epigenetic changes in brain regions associated with AUD. The study will analyze gene expression and DNA methylation patterns across 8 brain areas from 341 postmortem...
This federal Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA), under its Alcohol Research Programs (CFDA 93.273), aims to elucidate the molecular mechanisms underlying increased extracellular vesicle (EV) production in alcoholic liver disease. The $219,938 award, effective May 1, 2024 through April 30, 2026, will support research to determine how alcohol-induced autophagy deficiency and associated signaling pathways, including NRF2 and SDCBP2, contribute to...
The National Institute of General Medical Sciences (NIGMS) awarded a $607,916 project grant under the Biomedical Research and Research Training program (CFDA 93.859) to Kasa Bio, L.L.C., a woman-owned small business located in Peachtree Corners, Georgia. The purpose of this 1-year grant is to develop a multiplex real-time PCR (RT-qPCR) "Zip-Melt DLBCL Classifier Assay" to differentiate between the two major molecular subtypes of diffuse large B-cell lymphoma (DLBCL) - germinal center...

This Project Grant award of $273,974 from the National Institute on Alcohol Abuse and Alcoholism (NIAAA), under the Alcohol Research Programs (CFDA 93.273) federal grant program, supports the development of Kasa Bio, L.L.C.'s novel ZIP-MELT multiplex miRNA solution for liver disease screening.

The key product being developed is a cost-effective, eco-friendly RT-qPCR-based technology that can detect multiple miRNA biomarkers from various sample matrices in a single workflow. This solution aims to overcome limitations of current miRNA detection methods by enabling high-throughput, rapid analysis compared to existing single-plex qPCR assays. The proposed technology is expected to have a significant impact on translational research by providing an affordable multiplex miRNA qPCR solution for life sciences research and addressing the unmet need for molecular diagnostics in liver diseases, including alcohol-associated liver disease and non-alcoholic fatty liver disease.

Generated 4/29/25, 2:06 AM