Project Grant R41OD026567

This $543,351 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) is funding research to develop a novel transgenic mouse model to study the molecular and biochemical pathways disrupted by mutations in the MTFMT gene. MTFMT mutations are known to cause Leigh Syndrome, a severe mitochondrial disorder. The research aims to characterize the neurological and...

This three-year, $8.29 million project grant from the National Institutes of Health National Institute on Aging will support the development of full human gene replacement mouse models of Alzheimer's disease. Funded under the Aging Research program (CFDA 93.866), the Regents of the University of Minnesota will generate mouse lines with replacement of key Alzheimer's-related genes, including APP, PSEN1, PSEN2, MAPT, APOE, TREM2, MS4A, and INPP5D, with their full human orthologues. Control lines...

The National Institute of Child Health and Human Development (NICHD) awarded a $288,000 Project Grant titled "Fatty Acid Metabolism in Disease Models of Mitochondrial Fatty Acid Synthesis Deficiency" to the Van Andel Research Institute (VAI) in Michigan. This grant, funded under the NICHD's Child Health and Human Development Extramural Research program (CFDA 93.865), supports research aimed at identifying potential therapeutic targets to rescue growth and development in patient...

This Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), is funding research to investigate the role of mitochondrial specialization in early embryonic development. The $225,324 award to Duke University will support the development of a C. elegans model to study how the regulation of mitochondrial electron transport chain (ETC) complexes...

This $1,000,000 four-year Project Grant from the National Science Foundation's (NSF) Biological Sciences program (CFDA 47.074) will fund research at Northeastern University exploring the role of mitochondria in regulating cell fate decisions during early mammalian development. Specifically, the researchers will test the hypothesis that differential allocation of mitochondrial subtypes, which vary in biochemical properties and protein content including levels of the transcription factor TEAD4,...

The University of California, San Diego (UCSD) was awarded a $1,698,323 Project Grant from the National Institute on Aging (CFDA 93.866 Aging Research) to develop and validate a mouse model for Alzheimer's disease in Down syndrome (DS-AD). The goal is to create a genetically modified mouse that replicates key pathological features of DS-AD, including amyloid plaques, congophilic angiopathy, and neurofibrillary tangles. In the initial R61 phase, the researchers will demonstrate feasibility,...

This $844,954 Project Grant awarded by the National Institutes of Health (NIH) Office of the Director supports the development of "genomically rewritten and tailored humanized mouse models for various organ disorders" at New York University (NYU) School of Medicine. The project leverages advanced DNA technology to create mouse models that accurately reflect human disease susceptibility and pathology, enabling testing of novel therapies like gene editing and oligonucleotide...

This federal Project Grant award of $216,113.00 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) is supporting research to investigate the role of the GDF15-GFRAL signaling pathway in the development of mitochondrial myopathies. The primary objectives are to target the GDF15-GFRAL signaling mechanism to prevent and treat cachexia, a debilitating symptom of mitochondrial...

This federal Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), aims to study the relationship between mitochondrial dysfunction and the impact of non-syndromic autism spectrum disorder (ASD)-related risk genes on neuronal structure and function. The $253,500 award, provided from April 2025 to March 2027, will support the development of...

This Project Grant award of $605,000 from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), supports preclinical research to assess the restoration of an internally deleted dystrophin protein as a potential biomarker for a gene editing therapy targeting Duchenne muscular dystrophy (DMD). The project will utilize a humanized mouse model of DMD to evaluate how...