The University of California, San Diego (UCSD) was awarded a $1,698,323 Project Grant from the National Institute on Aging (CFDA 93.866 Aging Research) to develop and validate a mouse model for Alzheimer's disease in Down syndrome (DS-AD). The goal is to create a genetically modified mouse that replicates key pathological features of DS-AD, including amyloid plaques, congophilic angiopathy, and neurofibrillary tangles. In the initial R61 phase, the researchers will demonstrate feasibility, internal validation, and age-related phenotypes of the model. In the subsequent R33 phase, they will externally validate the model's face validity, construct validity, and predictive validity. This comprehensive model development and validation effort aims to accelerate understanding and treatment of DS-AD, a leading cause of death in the Down syndrome elderly population.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $1.7m | 8/15/24 |