Project Grant R21HD114905
- This $140,400 federal Project Grant was awarded on September 1, 2025 by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The grant aims to study the functions of lipid homeostasis during neural tube closure, a critical embryonic process for brain and spinal cord development. The research will use the FAF2 knockout mouse model to evaluate how dysregulation of lipid...
- This Project Grant award of $225,324, provided by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), supports research to understand the role of mitochondrial specialization in early development. The project aims to investigate how the mitochondrial electron transport chain (ETC) is regulated to meet the varying energetic and signaling demands of embryogenesis, using the C. elegans model...
- The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) awarded a $187,500 Project Grant on August 11, 2025 to the Pennington Biomedical Research Center in Louisiana. The grant, titled "BEYOND FOLATE - A SUPPLEMENTATION STRATEGY TO PREVENT NEURAL TUBE DEFECTS", falls under the NICHD's Child Health and Human Development Extramural Research program (CFDA 93.865). The project aims to investigate a novel nutritional approach to prevent neural tube...
- This federal Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), provides $466,125.00 to New York University School of Medicine to elucidate the role of mitochondrial function in rasopathies. The research aims to analyze mitochondrial morphology and function, including enzymatic activities and oxygen consumption, in tissues from a rasopathy mouse model. It will...
- The National Institute of Child Health and Human Development (NICHD) awarded a Project Grant of $107,948 to New York University (NYU) on June 20, 2025 under the Child Health and Human Development Extramural Research (CFDA 93.865) program. The grant aims to enhance the understanding of motor neuron differentiation, which is critical for addressing spinal muscular atrophy and amyotrophic lateral sclerosis - neurological disorders affecting nearly 1 in 10,000 people globally. The research will...
- The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research Federal Grant Program (CFDA 93.865), awarded a $131,166 Project Grant to the Rector & Visitors of the University of Virginia (UVA) to support research on the critical role of the SEL1L-HRD1 endoplasmic reticulum associated protein degradation (ERAD) pathway in neurodevelopment. The research aims to determine how disruption of this...
- This Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), provides $121,920 to investigate the role of the RFT1 protein in regulating growth and developmental signaling. The research aims to elucidate how RFT1, which is associated with a rare congenital disorder of glycosylation, impacts the Hedgehog signaling pathway and downstream mTOR Complex...
- This $1,615,502 federal Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) supports a comprehensive research initiative focused on advancing scientific understanding of fragile X-associated conditions (FXACs). The five-year research project led by the Regents of the University of Michigan aims to achieve a deeper understanding of the genetic,...
- This federal Project Grant award of $253,500.00 was provided by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865). The grant supports research conducted by the Icahn School of Medicine at Mount Sinai to investigate the relationship between mitochondrial dysfunction and the impact of non-syndromic autism spectrum disorder (ASD)-related risk genes on neuronal...
- This $429,000 Project Grant was awarded by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The grant supports research to define the impact of Kleefstra Syndrome-associated genomic variants within the ankyrin domain on the structural dynamics of the EHMT1 protein, and to elucidate the underlying biochemical and biophysical mechanisms of EHMT1 dysfunction caused by these variants. The...
This $288,000 Project Grant was awarded on August 4, 2025 by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research federal grant program (CFDA 93.865). The grant supports research conducted by the Van Andel Research Institute in Grand Rapids, Michigan to investigate fatty acid metabolism and identify potential therapeutic targets for treating mitochondrial fatty acid synthesis (MTFAS) deficiency disorders. The research aims to better understand the cellular roles of MTFAS products and the pathway's function, which is critical for developing rational therapies for MTFAS deficiency disorders like MEPAN syndrome. The project utilizes complementary methodologies, including a novel C. elegans model of MEPAN syndrome, to achieve these research goals and advance treatment options for this rare and debilitating group of pediatric mitochondrial diseases.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $288.0k | 8/4/25 | ||
| Not listed | $0 | 8/4/25 |