Project Grant R21NS145159
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $461,160 Project Grant to The Trustees of Columbia University in the City of New York under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The project, titled "From Metabolic Stress to Energy Enhancement: Unraveling Complex V Dimerization in Mitochondrial Disorders", aims to explore the role of ATP synthase dimerization in energy regulation and...
- This Project Grant award of $374,349 from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports the development and optimization of a new animal model for amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The goal is to create a mouse model that accurately recapitulates the human disease spectrum by incorporating an acetylation-mimicking...
- This Project Grant award, totaling $416,544.00, was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program. The award will support the establishment of novel non-invasive imaging for therapeutic efficacy (NITE) in a mouse model of Leigh syndrome, a rare and devastating childhood neurological disorder. The research aims to develop and validate the use...
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $1,540,579 project grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to the Regenerative Research Foundation in Rensselaer, NY. The 2-year grant, with a start date of June 1, 2025, will fund the development and validation of a novel, cellularly complex 3D human cell model of frontotemporal dementia (FTD) due to MAPT gene mutations. The goal is to create a model...
- This Project Grant award of $743,776 from the National Institute of Neurological Disorders and Stroke (NINDS, CFDA 93.853) supports research to determine whether and when ablating mutant cells that cause epilepsy can reverse the disease in mouse models of mTOR pathway disorders. The research aims to advance the development of AAV-mediated gene therapy approaches to treat intractable epilepsy caused by mTOR pathway mutations. This work builds upon almost two decades of the recipient...
- This Project Grant award of $532,381 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) supports research into the pathogenic mechanisms of the KIF5A gene mutation associated with amyotrophic lateral sclerosis (ALS). The key objectives of this 5-year research project are to: 1) determine the gain-of-function effects of the ALS-associated KIF5A exon 27 skipping variant...
- The National Institute on Aging (NIA) awarded a $310,083 Project Grant under the Aging Research federal grant program (CFDA 93.866) to the University of Arizona to investigate the role of the TMEM106B gene and mitochondrial dysfunction in frontotemporal lobar degeneration (FTLD) and other dementias. The research aims to determine if increased TMEM106B expression leads to changes in mitochondrial morphology, membrane potential, and respiration in cortical neurons, and to explore the mechanisms...
- This $135,960 project grant awarded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) supports research to investigate the molecular mechanisms underlying alterations to neuronal primary cilia in tuberous sclerosis complex (TSC). The principal goals are to determine whether astrocytic expression of HSP27 is necessary and/or sufficient to modulate cilia in TSC1-deficient...
- This federal Project Grant award of $459,000.00 from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, will support research to understand the anatomical and physiological changes accompanying neocortical malformations known as molecular layer heterotopia (MLH). The research will utilize GPR56 knockout mice to study the neuronal and glial changes in MLH using spatial...
- The National Institute of Neurological Disorders and Stroke (NINDS), through its Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program, awarded a $178,208 project grant to Northwestern University to elucidate the critical role of the mitochondrial enzyme MDH2 in the metabolism of GABAergic neurons. The research aims to investigate the necessity of MDH2 for ATP and GABA production in GABAergic neurons, which play a key role in...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $543,351 project grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to the Translational Genomics Research Institute (TGen) in Phoenix, Arizona. The grant funds the development and characterization of a novel transgenic mouse model to investigate the mechanisms by which mutations in the MTFMT gene disrupt mitochondrial translation and cause Leigh syndrome, a severe neurological disorder. The project aims to elucidate the molecular and biochemical pathways affected by the MTFMT C.626C>T mutation, which leads to reduced MTFMT protein levels and decreased oxidative phosphorylation. The research will focus on analyzing the neurological and behavioral phenotypes of the MTFMT mouse model to better understand the disease pathogenesis.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $543.4k | 7/31/25 |