This Project Grant from the National Institute on Aging, part of the Department of Health and Human Services, provides $4,563,558 under the Aging Research program (CFDA 93.866) to the Jackson Laboratory from September 15, 2022 to August 31, 2025. The funding supports research to model the genetic interaction between the Klotho and ApoE alleles in Alzheimer's disease. Specifically, the awardee will characterize new mouse models harboring relevant human variants in both Klotho and ApoE to...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $1,698,323.00 to the University of California, San Diego to develop and validate a mouse model for Alzheimer's disease in Down syndrome (DS-AD). The study aims to genetically modify the TcMAC21 mouse to replicate key pathological features of DS-AD, including amyloid plaques, congophilic angiopathy, and neurofibrillary tangles. The 3-year R61 phase will internally validate the mouse model by...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides funding of $136,032 to The Jackson Laboratory in Bar Harbor, Maine. The award supports research to investigate the role of the gene LRFN2 as a potential resilience factor against cortical neurodegeneration associated with Alzheimer's disease (AD). The project aims to develop a novel LRFN2 overexpression mouse model and evaluate its impact on AD-related cortical neurodegeneration,...
The National Institute on Aging awarded a $480,536 Project Grant under the Aging Research program (CFDA 93.866) to The Jackson Laboratory to fund research aimed at improving treatment for Alzheimer's disease and related dementias (ADRD). The project will assess whether manipulating the angiopoietin/tie2 (ANG/TIE2) signaling pathway can preserve blood-brain barrier (BBB) integrity and prevent cerebrovascular dysfunction, which are major contributors to many ADRDs. The research approach involves...
The National Institutes of Health's National Institute on Aging awarded a $7,432,562 project grant to the Regents of the University of California, San Francisco on September 15, 2022 under the Aging Research program (CFDA 93.866). The grant will support research to elucidate the roles of Alzheimer's disease risk genes and variants in gene expression and AD-related phenotypes through 2025. Specifically, the University of California, San Francisco will use CRISPR and single-cell RNA sequencing...
This Project Grant award in the amount of $640,895.00, titled "A MOUSE MODEL FOR BRAAK I/II ALZHEIMER'S PATHOLOGY", was provided by the National Institute on Aging under the Aging Research Federal Grant Program (CFDA 93.866). The goal of this study is to characterize a novel mouse mutant with a phenotype resembling Braak stage I/II Alzheimer's disease (AD) pathology and to develop this line into a novel animal model for AD research. Specifically, the project will: 1) Determine the...
This $5,274,018 project grant from the National Institute on Aging, part of the Department of Health and Human Services, supports research under the Aging Research program (CFDA 93.866). The J. David Gladstone Institutes will study the susceptibility and resistance to the detrimental effects of the Apolipoprotein E4 (APOE4) genetic risk factor for Alzheimer's disease. The research aims to characterize neurophysiological, behavioral, and neuropathological differences between new APOE4 mouse lines...
The National Institute on Aging (NIA), under its Aging Research program (CFDA 93.866), has awarded a $2,112,826 cooperative agreement to the University of California, San Diego (UCSD) to advance a CRISPR-based therapeutic for Alzheimer's disease (AD) towards pre-IND stage. The project aims to determine the optimal gene-editing combination to edit the APP gene, which plays a central role in AD pathogenesis, and shift the APP cleavage pathway from pathologic to physiologic. UCSD will evaluate...
This Project Grant award is funded by the National Institute on Aging (NIA) under the Aging Research Federal Grant Program (CFDA 93.866). The $2,319,456 award will support the University of California, San Diego in developing brain organoid models and leveraging multiomics techniques to investigate the mechanisms underlying Alzheimer's disease (AD) onset and progression. The key products and services to be delivered include: Derivation of 6 isogenic mutant and 3 mutant-corrected human induced...
The National Institute on Aging (NIA) awarded a $498,748 Project Grant under the Aging Research program (CFDA 93.866) to the University of Massachusetts Medical School (UMass Medical) to elucidate the mechanisms by which MS4A genes regulate neurodegeneration in Alzheimer's disease and related disorders. The project aims to investigate the effects of deleting various MS4A gene family members, individually or in combination, on neurodegenerative phenotypes across mouse models of Alzheimer's,...