Project Grant R41HD115418
Award Date
9/1/24
Completion Date
8/31/25
Dollars Obligated
$384K
Federal Agency
National Institute of Child Health and Human Development
Awardee
Serentrix LLC (EFCFK1FD41P5)
Federal Grant Program
93.865
Assistance Type
Project Grant
Place of Performance
Exton, PA 19341, USA
Similar Awards
This $509,220 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Drug Use and Addiction Research Programs (CFDA 93.279) aims to validate novel, non-hormonal, and non-opioid approaches for treating endometriosis-associated pain. The key products and services to be delivered through this award include: Identifying the inflammatory mediators and signaling pathways activated in macrophages upon stimulation by the neuropeptide CGRP, which...
This $2,045,782 Project Grant was awarded by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The funding supports the development of ENDO-205, a novel, non-hormonal therapeutic for endometriosis. Endometriosis is a prevalent and debilitating disease affecting approximately 10% of women worldwide, with no current cure. The grant enables the awardee, Endomet Biosciences, Inc., to...
This Project Grant award for $233,250.00, provided by the National Institute of Child Health and Human Development under the Child Health and Human Development Extramural Research program (CFDA 93.865), will support research to identify the mechanisms underlying endometriosis pain and changes in pain after lesion removal surgery. The key objectives of the research are to examine central mechanisms of inhibitory pain modulation capabilities and systemic estrogen levels, as well as peripheral...
This $643,049 Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), aims to develop a physiomimetic (tissue-engineered) model of the endometrioma lesion microenvironment. The project's objective is to investigate the processes responsible for the initiation and invasion of endometriosis lesions, which could inform the design of effective therapeutic strategies....
This federal Project Grant award of $794,894 from the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310) supports research to characterize key immune pathways that interact with hormonal responses in endometriosis. The primary awardee, the University of Texas Health Science Center at San Antonio, will utilize existing research infrastructure to collect endometriosis lesions, eutopic endometrium, peritoneal fluid, and peripheral...
The National Institute of Child Health and Human Development awarded a $2,163,115 Project Grant (CFDA 93.865 - Child Health and Human Development Extramural Research) to The University of Texas Health Science Center at San Antonio to conduct research on the genetic mechanisms underlying endometriosis severity. The project aims to characterize the epigenomic landscape of low and high-stage endometriosis using single-cell multi-omics methods, dissect allele-specific gene regulation mechanisms, and...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) under CFDA Program 93.859 (Biomedical Research and Research Training) aims to develop a novel topical treatment for burn pain by blocking cutaneous pain receptors. The $340,685 award to Serentrix LLC, a minority-owned for-profit organization, will fund the development of SER114, a topical small molecule antagonist of the TRPV1 receptor, as a treatment for cutaneous burn pain. The innovation lies in targeting...
This $20,000 federal Project Grant award from the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310) aims to develop a novel, noninvasive method for early detection of endometriosis using biological neural circuit-based gas sensors. The project, led by the collaborative research partnership of Henry Ford Health and Michigan State University Health Sciences, involves two key objectives: Detecting and distinguishing endometriosis...
This $6,154,752 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the federal Drug Use and Addiction Research Programs (CFDA 93.279), supports a 3-year clinical study to understand the interplay between menstrual pain (dysmenorrhea) and the development of chronic pelvic pain (CPP) conditions. The primary objectives are to determine if optimized anti-inflammatory (NSAID) treatment for menstrual pain can reduce the future risk of CPP, and to...
This $743,287 Project Grant award from the National Institute of Child Health and Human Development (CFDA 93.865 Child Health and Human Development Extramural Research program) supports a multi-disciplinary effort to uncover novel insights into endocervical mucus secretion and regulation by sex hormones. The goal is to leverage this understanding to inform the development of new non-hormonal therapeutics for contraception or fertility enhancement. The project combines a clinical trial model of...