Project Grant R41DC018250

This federal Project Grant award of $581,105 from the National Institute on Deafness and Other Communication Disorders (NIDCD) under the Research Related to Deafness and Communication Disorders program (CFDA 93.173) supports research to develop natural-based therapies for preventing hearing loss caused by aminoglycoside antibiotics. The key products and services being delivered include: Designing, synthesizing, and testing piperlongumine derivatives with improved pharmacological properties and...

This federal Project Grant award of $305,628 from the National Institute on Deafness and Other Communication Disorders (NIDCD) under the Research Related to Deafness and Communication Disorders program (CFDA 93.173) supports the development of a cell-type-specific gene therapy approach for TOMT-linked congenital hearing loss. The awardee, Echogenesis Therapeutics Inc., is using a computational platform to generate candidate cell-type-specific genomic promoter fragments for precise therapeutic...

The National Institute on Deafness and Other Communication Disorders (NIDCD) awarded Jacaranda Biosciences, Inc. a $304,762 SBIR Phase 1 Project Grant under the Research Related to Deafness and Communication Disorders program (CFDA 93.173). The funding will support the development of novel JBI compounds that function through the unfolded protein response (UPR) to prevent the ototoxicity and hearing loss caused by cisplatin chemotherapy treatment. The key objectives are to optimize the efficacy...

This Project Grant award from the National Institute on Deafness and Other Communication Disorders (NIDCD), under the Research Related to Deafness and Communication Disorders (CFDA 93.173) program, will fund the development of a CRISPR-based toolkit to investigate hair cell transcription factors in inner ear organoids. The $249,000 grant awarded to Merrimack College will enable the research team to: 1) Define the transcription factors involved in in vitro inner ear organoid hair cell development...

This federal Project Grant award of $582,552.00 from the National Institute on Deafness and Other Communication Disorders (NIDCD), under the Research Related to Deafness and Communication Disorders program (CFDA 93.173), aims to investigate the role of otoferlin in auditory circuit development and explore how gene therapy can restore hearing in patients with congenital deafness caused by otoferlin variants. The project, conducted by The Johns Hopkins University, seeks to understand how the...

This Project Grant award from the National Institute on Deafness and Other Communication Disorders (NIDCD), under the Research Related to Deafness and Communication Disorders program (CFDA 93.173), provides $767,494 to the University of Miami to develop human inner ear organoid platforms for studying genetic hearing loss and vestibular disorders. The key objectives are to: 1) establish and optimize human induced pluripotent stem cell-derived 3D inner ear organoid systems from patients with...

The National Institute on Deafness and Other Communication Disorders (NIDCD) awarded the University of Southern California (USC) a $456,500 Project Grant (CFDA 93.173) to develop a novel diagnostic test for sensory hearing loss. The "Gain-Sensitive Cochlear Microphonics" (GCM) test aims to assess the functional state and site of damage within the cochlear amplifier, which is crucial for hearing sensitivity and range. The proposed research will validate the GCM test in mice by comparing...

This federal Project Grant award of $265,410 from the National Institute on Deafness and Other Communication Disorders (NIDCD) under the Research Related to Deafness and Communication Disorders program (CFDA 93.173) supports research to characterize how heterogeneous regional expression of mechanoelectrical transduction (MET) channel components contributes to vestibular hair cell function and development, and whether early MET expression defines a critical period for gene replacement therapy....

The National Institute on Deafness and Other Communication Disorders (NIDCD) awarded a $410,534 Project Grant to The Medical University of South Carolina (MUSC) under the Research Related to Deafness and Communication Disorders program (CFDA 93.173). The grant, awarded on September 10, 2025, seeks to identify genetic modifiers that influence the penetrance of hearing impairment in the context of Endothelin receptor EDNRB deficiency. The research aims to address the role of the KCNJ16 gene, which...

This $473,749 Project Grant was awarded by the National Institute on Deafness and Other Communication Disorders (NIDCD) under the Research Related to Deafness and Communication Disorders program (CFDA 93.173) on September 11, 2025. The grant is for a project titled "In-silico Screen and In-vivo Evaluation of FDA-Approved Drugs to Treat Noise-Induced Hearing Loss" conducted by the Massachusetts Eye And Ear Infirmary, a non-profit hospital and research institution affiliated with Harvard...