This Project Grant award from the National Institute on Deafness and Other Communication Disorders (NIDCD), under the Research Related to Deafness and Communication Disorders program (CFDA 93.173), provides $581,105 to Creighton University to develop natural-based therapies for treating hearing loss caused by aminoglycoside antibiotics. The key focus is on designing, synthesizing, and testing piperlongumine derivatives that can better target the TRPV1 channel to protect hair cells and synapses...
The National Institute on Deafness and Other Communication Disorders (NIDCD) awarded a $115,707 Project Grant under the CFDA 93.173 Research Related to Deafness and Communication Disorders program to the Rector & Visitors of the University of Virginia (UVA). The grant supports research investigating how phospholipid homeostasis regulates hair cell function and health, using mouse models deficient in the phospholipid flippase ATP8B1 or its cofactor TMEM30B. The research aims to uncover the...
This Project Grant award from the National Institute on Deafness and Other Communication Disorders (NIDCD), under the Research Related to Deafness and Communication Disorders program (CFDA 93.173), provides $767,494 to the University of Miami to develop human inner ear organoid platforms for studying genetic hearing loss and vestibular disorders. The key objectives are to: 1) establish and optimize human induced pluripotent stem cell-derived 3D inner ear organoid systems from patients with...
The National Institute on Deafness and Other Communication Disorders (NIDCD) awarded a $415,743 Project Grant under the Research Related to Deafness and Communication Disorders program (CFDA 93.173) to Oregon Health & Science University (OHSU). The 5-year grant, effective February 1, 2025, will support research to investigate the role of macrophages in the development, homeostasis, and repair of the tympanic membrane (eardrum). The project aims to characterize the origin and function of...
The National Institute on Deafness and Other Communication Disorders (NIDCD) awarded the University of Southern California (USC) a $456,500 Project Grant (CFDA 93.173) to develop a novel diagnostic test for sensory hearing loss. The "Gain-Sensitive Cochlear Microphonics" (GCM) test aims to assess the functional state and site of damage within the cochlear amplifier, which is crucial for hearing sensitivity and range. The proposed research will validate the GCM test in mice by comparing...
This federal Project Grant award of $781,703, awarded by the National Institute on Deafness and Other Communication Disorders (NIDCD) under CFDA 93.173 "Research Related to Deafness and Communication Disorders", supports research to better understand sensory development in human cochlear organoids. The goals are to define the developmental trajectories of key sensory cell types, test methods to increase the number of hair cells, and accelerate the maturation of hair cells and sensory...
This Project Grant award from the National Institute on Deafness and Other Communication Disorders (NIDCD) under CFDA 93.173 "Research Related to Deafness and Communication Disorders" provides $637,500.00 to the Massachusetts Eye and Ear Infirmary to conduct research on understanding human cochlear micromechanics. The goal is to study the forward transduction that drives inner and outer hair cell stereocilia, as well as the reverse transduction that amplifies organ of Corti motion...
This federal Project Grant award from the National Institute on Deafness and Other Communication Disorders (NIDCD) under the Research Related to Deafness and Communication Disorders program (CFDA 93.173) will support research on the genetic causes of adult-onset hearing loss. The $676,533 award to the University of Pennsylvania aims to elucidate the role of the ZNF175/ZFP719 gene in pathogenic mechanisms leading to hearing loss, including investigating its effects on auditory synapses, ion...
The National Institute on Deafness and Other Communication Disorders (NIDCD) awarded a $307,962 Project Grant under the CFDA 93.173 Research Related to Deafness and Communication Disorders program to Restorear Devices LLC, a medical technology company based in Bozeman, Montana. The project aims to test whether the non-invasive, non-pharmaceutical delivery of mild therapeutic hypothermia can provide symptomatic relief and reduce the severity of tinnitus, a common and debilitating medical...
This $659,164 Project Grant awarded by the National Institute on Deafness and Other Communication Disorders (NIDCD), under the Research Related to Deafness and Communication Disorders program (CFDA 93.173), aims to identify pharmacological modulators, endogenous ligands, and binding partners for the orphan G protein-coupled receptor GPR156. The grant, awarded to the University of Rochester, will leverage innovative cell-based assays and proximity-mediated labeling technologies to discover new...