Project Grant R01DC021954

Award Date 4/15/25
Completion Date 3/31/30
Dollars Obligated $581K
Federal Grant Program
93.173
Assistance Type
Project Grant
Place of Performance
Omaha, NE 68178, USA
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The federal Project Grant award R01DC021954, totaling $581,105.00, was granted by the National Institute on Deafness and Other Communication Disorders (NIDCD) under the Research Related to Deafness and Communication Disorders program (CFDA 93.173). The grant supports research to develop natural-based therapies for preventing aminoglycoside-induced hearing loss, a significant health concern affecting 40-60% of patients receiving this common antibiotic treatment. The research, conducted by Creighton University, a private non-profit research institution, aims to design, synthesize, and test derivatives of the natural compound piperlongumine to target the TRPV1 channel and protect inner ear hair cells and synapses. The project will characterize the pharmacological properties of lead candidates, establish efficacy and therapeutic windows in animal models, and confirm the mechanism of action while ensuring the compounds do not interfere with the antibacterial activity of aminoglycosides. This work has the potential to advance a promising therapeutic intervention for aminoglycoside-induced hearing loss towards future clinical trials.

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