Project Grant R21DC022934
- This $533,978 Project Grant award from the National Institute on Deafness and Other Communication Disorders (NIDCD), under the federal Research Related to Deafness and Communication Disorders program (CFDA 93.173), will support research to uncover the molecular basis of otosclerosis. The project aims to analyze rare and common genomic variants in a large cohort of otosclerosis cases and families, as well as identify epigenetic factors implicated in the disease, using advanced genomic and...
- The National Institute on Deafness and Other Communication Disorders (NIDCD), under the CFDA program "Research Related to Deafness and Communication Disorders", awarded a $193,750.00 Project Grant to The Johns Hopkins University. The grant, effective April 1, 2025 through March 31, 2028, will fund research to investigate the neural dynamics and underlying mechanisms in the auditory cortex during implicit learning of complex sounds. The research aims to map the neural circuits...
- This federal Project Grant award of $305,628 from the National Institute on Deafness and Other Communication Disorders (NIDCD) under the Research Related to Deafness and Communication Disorders program (CFDA 93.173) supports the development of a cell-type-specific gene therapy approach for TOMT-linked congenital hearing loss. The awardee, Echogenesis Therapeutics Inc., is using a computational platform to generate candidate cell-type-specific genomic promoter fragments for precise therapeutic...
- This Project Grant award from the National Institute on Deafness and Other Communication Disorders (NIDCD), under the Research Related to Deafness and Communication Disorders program (CFDA 93.173), provides $767,494 to the University of Miami to develop human inner ear organoid platforms for studying genetic hearing loss and vestibular disorders. The key objectives are to: 1) establish and optimize human induced pluripotent stem cell-derived 3D inner ear organoid systems from patients with...
- This $115,158 Project Grant, awarded on February 1, 2025 by the National Institute on Deafness and Other Communication Disorders (NIDCD) under the federal Research Related to Deafness and Communication Disorders program (CFDA 93.173), supports research into the neurological mechanisms underlying hearing loss. The central hypothesis is that the presentation of phosphatidylserine acts as a signal to mark inactive spiral ganglion neuron connections with outer hair cells for removal, facilitating...
- This $146,206 Project Grant award from the National Institute on Deafness and Other Communication Disorders (NIDCD), part of the federal Research Related to Deafness and Communication Disorders program (CFDA 93.173), will support research to understand the role of auditory cortex and subcortical regions in learning and retaining associations between sounds and behavioral outcomes in mice. The research aims to investigate how the auditory cortex may train subcortical regions like the medial...
- This federal Project Grant award of $147,486, provided by the National Institute on Deafness and Other Communication Disorders (NIDCD) under the Research Related to Deafness and Communication Disorders program (CFDA 93.173), will support research to investigate the neural circuitry involved in the categorization of auditory stimuli in mice. The primary objectives are to examine auditory cortical population dynamics during the categorization of unfamiliar pure tones, identify relevant neural...
- The National Institute on Deafness and Other Communication Disorders (NIDCD) awarded a $410,534 Project Grant to The Medical University of South Carolina (MUSC) under the Research Related to Deafness and Communication Disorders program (CFDA 93.173). The grant, awarded on September 10, 2025, seeks to identify genetic modifiers that influence the penetrance of hearing impairment in the context of Endothelin receptor EDNRB deficiency. The research aims to address the role of the KCNJ16 gene, which...
- This federal Project Grant award for $486,750.00 was provided by the National Institute on Deafness and Other Communication Disorders (NIDCD) under the Research Related to Deafness and Communication Disorders (CFDA 93.173) program. The grant supports research to explore the morphological changes and cell polarity mechanisms in supporting cells of the inner ear, which play a critical role in auditory function. The primary awardee, the Jackson Laboratory, a nonprofit biomedical research...
- The University of Pittsburgh received a $610,725 Project Grant award from the National Institute on Deafness and Other Communication Disorders (NIDCD) under the federal Research Related to Deafness and Communication Disorders program (CFDA 93.173) effective May 2, 2025 with a completion date of April 30, 2030. The project will characterize the physiological mechanisms contributing to "suprathreshold deficits" in sensorineural hearing loss, where individuals struggle to understand...
This federal Project Grant award of $582,552.00 from the National Institute on Deafness and Other Communication Disorders (NIDCD), under the Research Related to Deafness and Communication Disorders program (CFDA 93.173), aims to investigate the role of otoferlin in auditory circuit development and explore how gene therapy can restore hearing in patients with congenital deafness caused by otoferlin variants. The project, conducted by The Johns Hopkins University, seeks to understand how the absence of otoferlin affects spontaneous neural activity and auditory cortex organization in otoferlin knockout mice, as well as examine the impact of otoferlin gene therapy on auditory system plasticity at different developmental stages. The findings from this research are expected to provide insights into optimizing gene therapy approaches to restore hearing in individuals with congenital deafness related to otoferlin deficiencies.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $582.6k | 7/29/25 |