Project Grant R21DC022085
- The Department of Defense's Military Medical Research and Development program (CFDA 12.420) awarded a $358,245 Project Grant to the Massachusetts Eye And Ear Infirmary on May 15, 2024 for the project "IN SILICO SCREEN AND IN VIVO EVALUATION OF FDA-APPROVED DRUGS TO TREAT NOISE-INDUCED HEARING LOSS". The grant supports a two-year effort to screen FDA-approved drugs and evaluate the most promising compounds for their ability to protect against noise-induced hearing loss in cell...
- This federal Project Grant award of $673,048 was provided by the National Institute on Deafness and Other Communication Disorders (NIDCD) under the Research Related to Deafness and Communication Disorders program (CFDA 93.173). The objective is to investigate the role of mitochondrial calcium regulation in cochlear hair cells and its contribution to acquired hearing loss, with a focus on assessing the impact of acoustic overstimulation and developing strategies to mitigate noise-induced...
- This federal Project Grant award of $131,408 from the National Institute on Deafness and Other Communication Disorders (CFDA 93.173 - Research Related to Deafness and Communication Disorders) supports research on the impact of noise-induced hearing loss on neural representations and processing in the auditory cortex and amygdala. The primary awardee, Massachusetts Eye and Ear Infirmary, will leverage advanced imaging and recording techniques to investigate how hearing loss leads to maladaptive...
- This Project Grant award of $637,500.00 was provided by the National Institute on Deafness and Other Communication Disorders (NIDCD) under the federal Research Related to Deafness and Communication Disorders program (CFDA 93.173). The goal of the project is to understand the forward transduction that drives inner and outer hair cell stereocilia, as well as the reverse transduction that amplifies motion in the human cochlea, using a novel finite element modeling technique. The research will focus...
- This $115,158 Project Grant, awarded on February 1, 2025 by the National Institute on Deafness and Other Communication Disorders (NIDCD) under the federal Research Related to Deafness and Communication Disorders program (CFDA 93.173), supports research into the neurological mechanisms underlying hearing loss. The central hypothesis is that the presentation of phosphatidylserine acts as a signal to mark inactive spiral ganglion neuron connections with outer hair cells for removal, facilitating...
- This federal Project Grant award from the National Institute on Deafness and Other Communication Disorders (NIDCD), under the Research Related to Deafness and Communication Disorders program (CFDA 93.173), will support research to investigate the neural mechanisms underlying the processing of complex sounds in the auditory cortex following noise-induced hearing loss. The $131,555 award to Oregon Health & Science University will fund large-scale neural recordings and the development of...
- This $369,806 Project Grant from the National Institutes of Health's National Institute on Deafness and Other Communication Disorders will fund research into objective screening tests for noise-induced hearing damage. The University of Wisconsin-Madison will investigate short- and long-term changes in cochlear, afferent, and efferent auditory system function due to noise exposure using otoacoustic emission-based assays of the middle ear muscle reflex and medial olivocochlear reflex....
- The National Institute on Deafness and Other Communication Disorders (NIDCD) awarded a $311,029 Project Grant under the Research Related to Deafness and Communication Disorders (CFDA 93.173) program to Creare LLC, a small business based in Hanover, New Hampshire. The funding will support the design, development, and testing of a multi-function earplug that can provide hearing protection, record personal noise dose, and monitor hearing function over time. This integrated in-ear hearing monitoring...
- This federal Project Grant award of $102,324 from the National Institute on Deafness and Other Communication Disorders (NIDCD) under the Research Related to Deafness and Communication Disorders program (CFDA 93.173) supports research to investigate the role of macrophage/microglia dysfunction in age-related auditory nerve degeneration and hearing loss. The 2-year project, running from September 2025 to August 2027, will be conducted by the Medical University of South Carolina. The research...
- This federal Project Grant award of $581,105 from the National Institute on Deafness and Other Communication Disorders (NIDCD) under the Research Related to Deafness and Communication Disorders program (CFDA 93.173) supports research to develop natural-based therapies for preventing hearing loss caused by aminoglycoside antibiotics. The key products and services being delivered include: Designing, synthesizing, and testing piperlongumine derivatives with improved pharmacological properties and...
This $473,749 Project Grant was awarded by the National Institute on Deafness and Other Communication Disorders (NIDCD) under the Research Related to Deafness and Communication Disorders program (CFDA 93.173) on September 11, 2025. The grant is for a project titled "In-silico Screen and In-vivo Evaluation of FDA-Approved Drugs to Treat Noise-Induced Hearing Loss" conducted by the Massachusetts Eye And Ear Infirmary, a non-profit hospital and research institution affiliated with Harvard Medical School. The project aims to expedite the development of novel treatments for noise-induced hearing loss, a prevalent occupational injury that leads to permanent cellular damage in the inner ear. The research will focus on modulating the mitochondrial calcium uniporter (MCU) complex, a key regulator of mitochondrial function, through the repurposing of FDA-approved drugs. This approach seeks to prevent noise-induced auditory damage and maintain hearing function. The project will involve in-silico screening and in-vivo evaluation of candidate drugs, with the goal of translating scientific discoveries into potential clinical interventions for acquired hearing loss.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $473.7k | 9/11/25 |