This $382,500 five-year Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under CFDA 93.855 Allergy and Infectious Diseases Research supports research at Washington State University to study the functional and mechanistic aspects of the Lyme disease spirochete's genetic factors encoded on plasmid LP17. The key objectives are to: 1) Establish the importance of genes BBD21 and BBD22 for controlling the copy number of Borrelia burgdorferi plasmids and the...
The Virginia Commonwealth University was awarded a $746,009 Project Grant from the Department of Health and Human Services National Institutes of Health National Institute of Allergy and Infectious Diseases. The grant falls under the Allergy and Infectious Diseases Research program (CFDA 93.855) to support research examining the cyclic-di-GMP signaling pathway and its role in the enzootic cycle of Lyme disease from November 18, 2022 through October 31, 2027. Specifically, the grant will fund...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $191,250 to support research on the role of genetic factors in antigenic variation of the VlsE surface protein of the Lyme disease spirochete, Borrelia burgdorferi. The goal is to decipher the mechanistic details of cis-acting factors involved in VlsE expression and gene conversion, which is a key mechanism for...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $192,500.00 to the University of South Alabama to investigate the mechanisms of central nervous system invasion by the Lyme disease pathogen, Borrelia burgdorferi. The research aims to: Determine the role of the blood-cerebrospinal fluid barrier as a site for B. burgdorferi and immune cell entry into the...
The Project Grant award, with Federal Grant Award ID R41AI179571, is provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The $300,000 award, effective July 17, 2024 through June 30, 2026, supports the development of a broad-spectrum prophylactic for tick-borne diseases, specifically Lyme disease and relapsing fever. The grantee, Planet Biotechnology Incorporated, will use a plant-based...
This federal Project Grant award in the amount of $3,019,293 was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The award supports a prospective 5-year study to investigate the causes and mechanisms of Post-Treatment Lyme Disease Syndrome (PTLDS), a complex condition that lacks consensus on diagnosis and treatment. The study is being conducted by a multidisciplinary team of clinicians,...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $426,648 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the Dartmouth-Hitchcock Clinic. The grant, titled "ADVANCING ANTIMICROBIAL PHOTODYNAMIC THERAPY TO PREVENT INFECTION IN OSSEOINTEGRATED PROSTHESIS PATIENTS," will fund research to develop antimicrobial photodynamic therapy for preventing infections in patients with osseointegrated prosthetic implants. As part of...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), totaling $198,720.00, aims to study post-infectious dysautonomia, a common and disabling syndrome that can occur following COVID-19 and Lyme disease. The research objectives include: 1) identifying distinct clinical subgroups of post-infectious dysautonomia through data analysis, 2) determining the clinical significance...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $299,969 Project Grant to L2 Diagnostics LLC under the Allergy and Infectious Diseases Research program (CFDA 93.855). The grant supports research to evaluate a mosquito salivary protein, AGBR1, as a potential vaccine candidate against Chikungunya virus, an arboviral disease transmitted by infected mosquitoes. The project aims to conduct comparative assessments of different AGBR1 vaccine formulations, including...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $509,130 to the University of South Florida to conduct research on the global virulence regulatory network in the Lyme disease pathogen Borrelia burgdorferi (BB). The key objectives are to: 1) define the regulon (set of genes) controlled by the BosR regulator and characterize the contributions of BosR-regulated...