The National Institute of Allergy and Infectious Diseases (NIAID) awarded a 5-year, $7,539,599 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to Tufts University School of Medicine to conduct a prospective study on Post-Treatment Lyme Disease Syndrome (PTLDS). The study aims to better understand the underlying mechanisms of PTLDS through comprehensive diagnostic testing, biomarker discovery, and collaborative research involving clinicians, epidemiologists, immunologists, and microbiologists. The study will enroll and follow subjects from acute Lyme disease diagnosis through recovery or development of PTLDS, and establish a large, well-characterized specimen biorepository to facilitate ongoing and future research. Key deliverables include identifying differences in co-infections, inflammatory patterns, cell types and reactions, autoantibody formation, antibiotic resistance, and bacterial characteristics between PTLDS and recovered Lyme disease patients. Tufts University has sub-awarded portions of the work to Massachusetts General Hospital for diagnostic testing and sample processing, and to MaineHealth and Tufts Medical Center for clinical coordination and data management support.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $4.5m | 7/2/25 | ||
| Not listed | $3.0m | 9/5/24 |
Grant Number | Description | Subgrantee | Prime Award | Dollars Obligated (Click to sort descending) | Updated At (Click to sort ascending) |
|---|---|---|---|---|---|
EP0248965S | The General Hospital Corporation | Project Grant P01AI181934 | $346.8k | 3/17/25 | |
EP0247370S | Mainehealth | Project Grant P01AI181934 | $545.9k | 1/14/25 | |
EP0246436S | Tufts Medical Center Parent, Inc. | Project Grant P01AI181934 | $34.7k | 12/9/24 |