The University of South Florida was awarded a $509,130 Project Grant by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The grant supports research to define the role of the BosR regulator in controlling virulence gene expression and the infectious cycle of the Lyme disease pathogen Borrelia burgdorferi. Key objectives include characterizing the BosR regulon, examining the regulation of BosR expression,...
This Project Grant award of $461,375.00 from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports research at Yale University to systematically identify interactions between Lyme disease bacteria, Borrelia burgdorferi, and proteins from its tick vector, Ixodes scapularis. The goal is to develop a comprehensive database of these pathogen-vector interactions, which can inform strategies to block transmission or interrupt the...
This $382,500 five-year Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under CFDA 93.855 Allergy and Infectious Diseases Research supports research at Washington State University to study the functional and mechanistic aspects of the Lyme disease spirochete's genetic factors encoded on plasmid LP17. The key objectives are to: 1) Establish the importance of genes BBD21 and BBD22 for controlling the copy number of Borrelia burgdorferi plasmids and the...
This Project Grant award of $191,250 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research by Washington State University to study the mechanism of antigenic variation in the Lyme disease spirochete, Borrelia burgdorferi. The research aims to decipher the role of specific genetic factors in the expression and recombination of the VlsE surface protein, which is a key mechanism for immune...
The federal Project Grant award R01AI186279 of $1,663,244.00, awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to characterize innate immune signaling pathways in the tick Ixodes scapularis. The project aims to improve understanding of immune signaling in ticks, which are vectors of Lyme and other emerging diseases, by combining cell culture-based methods with in vivo assays in...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research (CFDA 93.855) program, provides $162,000.00 to The Johns Hopkins University to conduct research on how the spirochete Borrelia burgdorferi, the causative agent of Lyme disease, uses epidermal growth factor (EGF) as an environmental cue to coordinate its gene expression during the infection cycle. The research aims to characterize the binding of EGF...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $192,500.00 to the University of South Alabama to conduct research on the mechanisms of Borrelia burgdorferi central nervous system invasion in a mouse model of Lyme disease. The goal is to identify key pathways of bacterial entry into the central nervous system and associated host immune responses, which could...
This Project Grant award, valued at $165,000.00, was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The purpose of the award is to develop an improved transposon mutagenesis system for comprehensive genetic analysis of Borrelia burgdorferi, the bacterium that causes Lyme disease. The project aims to create a high-efficiency transposon insertional mutagenesis system and use transposon...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $436,144 to Virginia Commonwealth University (VCU) to study the mechanisms by which the intracellular bacterium Anaplasma phagocytophilum exploits the host's regulated exocytosis process for its own dissemination and infection. The research aims to investigate the roles of calcium, sphingosine-1-phosphate, and the...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $135,258 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to Virginia Polytechnic Institute & State University (Virginia Tech) on September 13, 2024. The grant will fund research to determine the biochemical features of Treponema pallidum peptidoglycan and the identity of released muropeptides, as well as elucidate the role of released peptidoglycan in the pathogenesis of...