Project Grant R35GM166242
- The National Institute of General Medical Sciences awarded The Pennsylvania State University $432,575 on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop and validate technologies for controlled three-dimensional protein condensation to improve cryo-electron tomography sample preparation. The project addresses air-water interface damage that compromises sample quality and limits cryo-EM applications to many biological systems. The recipient...
- The National Institute of General Medical Sciences awarded The Pennsylvania State University $425,667 on March 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate the molecular mechanisms of chromatin remodeling and histone deacetylation. The recipient's research program examines ATP-dependent chromatin remodelers, specifically CHD and ISWI ATPases, and sirtuins, NAD-dependent histone deacetylases, two enzyme families that dynamically regulate...
- The National Institute of General Medical Sciences awarded The Pennsylvania State University $432,575 on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate the molecular pharmacology and physiology of ghrelin receptor functional selectivity. The research examines two clinically relevant principles of G protein-coupled receptor (GPCR) pharmacology: functional selectivity (the asymmetric engagement of intracellular transducers such as G...
- The National Institute of General Medical Sciences awarded The Pennsylvania State University $407,603 on March 5, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate brain-body allostasis via longitudinal in vivo imaging. The research examines how astrocytes—non-neuronal glial cells in the brain—coordinate physiological state shifts and facilitate whole-body allostasis during stress response. The study uses simultaneous in vivo recording of...
- The National Institute of General Medical Sciences awarded The Pennsylvania State University $400,969 on April 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop phenotype control methods for guided manipulation of cell behavior and fate. The research advances two phenotype control approaches applicable to biomolecular systems. Feedback Vertex Set (FVS) Control, based on interaction networks underlying biological systems, will be refined to overcome the...
- The National Institute of General Medical Sciences awarded the University of Pennsylvania $441,826 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate the molecular basis of transcription initiation at eukaryotic promoters in chromatin. The research will isolate and dissect pre-initiation complex (PIC)-mediator-coactivator complexes representing states from initiation to early elongation, using biochemical and structural approaches...
- The National Institute of General Medical Sciences awarded $406,250 to the University of Pennsylvania on March 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop statistical and computational methods for analyzing complex multimodal biological datasets. The recipient will develop correlated latent factor models to extend multi-omic inference capabilities across complex study designs, including model-based imputation methods for handling missing data...
- The National Institute of General Medical Sciences awarded The Pennsylvania State University $750,554 on April 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate mechanisms and control of oxygen and carbon-hydrogen activation within enzyme architectures. The award supports a five-year project through March 31, 2031, with performance at Penn State's State College, Pennsylvania campus. The research program examines three classes of metalloenzymes that...
- The National Institute of General Medical Sciences awarded The Pennsylvania State University $440,259 in a Project Grant (R35GM163932) on September 1, 2026, to investigate the mechanobiology of epithelial-mesenchymal plasticity. The research examines how combined effects of matrix elasticity and viscosity regulate epithelial cell plasticity and fate decisions in response to transforming growth factor (TGF)-β1 stimulation. The project synthesizes and characterizes hydrogels with independent and...
- This federal Project Grant award from the National Science Foundation's Biological Sciences program (CFDA 47.074) provides $776,309 to The Pennsylvania State University to conduct research on the structural responses of intrinsically disordered proteins to chemical modifications that regulate gene expression. The project aims to develop new experimental methodology for nuclear magnetic resonance (NMR) spectroscopy to gain quantitative insights into these regulatory mechanisms. The research...
The National Institute of General Medical Sciences awarded The Pennsylvania State University $419,939 on August 1, 2026, to conduct live-cell super-resolution imaging research on enhancer-mediated gene bursting under the Biomedical Research and Research Training program (CFDA 93.859). The research characterizes transcriptional condensates—assemblies of RNA Polymerase II, Mediator, and transcription activators—in mouse embryonic stem cells and examines how they regulate target gene expression within three-dimensional genome architecture. The work proceeds along two tracks: investigation of condensate function and dynamics at the single-cell level, including specificity, formation and dissolution mechanisms, and regulation by genome architecture; and study of differential gene regulation during development using beta-globin regulation in mouse erythroleukemia cells as a model system. The research develops new labeling strategies to image enhancer RNAs and their roles in condensate function, tests whether transcriptional condensates co-activate reporter genes with varying promoter specificity, and selectively manipulates chromosomal interactions to understand condensate-regulatory element interactions. Performance occurs in State College, Pennsylvania. The period of performance runs from August 1, 2026, through April 30, 2031. The assistance type is a Project Grant.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $419.9k | 7/24/26 |