Project Grant R21GM164827
- The National Institute of General Medical Sciences awarded The Pennsylvania State University $419,939 on August 1, 2026, to conduct live-cell super-resolution imaging research on enhancer-mediated gene bursting under the Biomedical Research and Research Training program (CFDA 93.859). The research characterizes transcriptional condensates—assemblies of RNA Polymerase II, Mediator, and transcription activators—in mouse embryonic stem cells and examines how they regulate target gene expression...
- The National Institute of General Medical Sciences awarded Quantumbio Inc. $1.192781 million on September 30, 2025, under the Biomedical Research and Research Training program (CFDA 93.859) to develop a unified X-ray and cryo-EM ensemble refinement toolkit that integrates quantum mechanics/molecular mechanics (QM/MM) methods with enhanced density-driven molecular dynamics to address structural disorder and conformational heterogeneity in protein-ligand interactions for drug discovery...
- This federal Project Grant award from the National Science Foundation's Biological Sciences program (CFDA 47.074) provides $776,309 to The Pennsylvania State University to conduct research on the structural responses of intrinsically disordered proteins to chemical modifications that regulate gene expression. The project aims to develop new experimental methodology for nuclear magnetic resonance (NMR) spectroscopy to gain quantitative insights into these regulatory mechanisms. The research...
- The National Institute of General Medical Sciences awarded The Pennsylvania State University $425,667 on March 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate the molecular mechanisms of chromatin remodeling and histone deacetylation. The recipient's research program examines ATP-dependent chromatin remodelers, specifically CHD and ISWI ATPases, and sirtuins, NAD-dependent histone deacetylases, two enzyme families that dynamically regulate...
- The National Institute of General Medical Sciences awarded Texas A&M University System Health Science Center $420,657 on July 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859, assistance type Project Grant) to support research on nanoscale structure and dynamics within nuclear pores and condensates. The funded research examines intrinsically disordered proteins and regions in the proteome, with focus on transport properties of the nuclear pore complex and...
- The National Institute of General Medical Sciences awarded The Pennsylvania State University $750,554 on April 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate mechanisms and control of oxygen and carbon-hydrogen activation within enzyme architectures. The award supports a five-year project through March 31, 2031, with performance at Penn State's State College, Pennsylvania campus. The research program examines three classes of metalloenzymes that...
- The National Science Foundation Division of Chemistry awarded The Pennsylvania State University $650,000 on September 1, 2026, under the Mathematical and Physical Sciences program (CFDA 47.049) for fundamental research into how interfacial potential and surface tension govern the solubility of thermoresponsive polymers in aqueous solutions. Dr. Paul S. Cremer's research team will investigate liquid-liquid phase separation of polymer molecules in the presence of Hofmeister salts and osmolytes,...
- The National Institute of General Medical Sciences awarded The Pennsylvania State University $440,259 in a Project Grant (R35GM163932) on September 1, 2026, to investigate the mechanobiology of epithelial-mesenchymal plasticity. The research examines how combined effects of matrix elasticity and viscosity regulate epithelial cell plasticity and fate decisions in response to transforming growth factor (TGF)-β1 stimulation. The project synthesizes and characterizes hydrogels with independent and...
- The National Institute of General Medical Sciences, part of the National Institutes of Health, awarded $345,581 to the University of Pennsylvania on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to visualize and characterize how bacteria and archaea use DNA-bending proteins to fold genomic DNA into three-dimensional shapes that regulate CRISPR-associated integrase function during adaptive immunity to phage infection. The project will employ...
- The National Institute of General Medical Sciences awarded Temple University $500,594 on July 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop methods combining deep generative models and molecular simulation for understanding protein conformational dynamics and molecular binding interactions. The research extends the Bayesian Inference of Conformational Ensembles with Score for Model Selection (BICEPS) method for use with deep generative models to...
The National Institute of General Medical Sciences awarded The Pennsylvania State University $432,575 on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop and validate technologies for controlled three-dimensional protein condensation to improve cryo-electron tomography sample preparation. The project addresses air-water interface damage that compromises sample quality and limits cryo-EM applications to many biological systems. The recipient will develop a toolkit termed NAP3D (No AWI Problems in 3D) through two primary aims. Aim 1 develops chemically induced condensate air-water interface shielding technologies applicable to all proteins, exploring two strategies: inducing protective phase separation through controlled solubility modulation using reagents such as polyethylene glycol and ammonium sulfate, and constructing affinity-mediated condensates based on biotin-streptavidin network interactions. Aim 2 engineers and validates plug-and-play genetically encoded platforms for defined three-dimensional protein network formation, primarily through symmetry-dependent dual strep-tagging of target proteins. The approach forms 200–300 nanometer-thick protein condensates where interior proteins remain protected from air-water interface exposure while maintaining random orientations for isotropic reconstruction quality in cryo-electron tomography and sub-tomogram averaging analysis. Work is performed in State College, Pennsylvania, with a period of performance from August 1, 2026, through July 31, 2028. This is a Project Grant assistance type.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $432.6k | 7/30/26 |