Project Grant R35GM161264
- Federal Grant Award Summary The University of Pennsylvania received a $406,250 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective June 1, 2025, through April 30, 2030. This award supports fundamental research investigating two interconnected research directions: (1) transcription factor (TF) functional divergence and how members of TF families coordinate complex developmental...
- Federal Project Grant Award Summary The University of Pennsylvania received a $406,250 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective March 1, 2026, with completion targeted for December 31, 2030. The award funds the development of correlated factor models and statistical methodologies for analyzing complex multimodal biological datasets. The project will deliver three...
- Federal Grant Award Summary The Pennsylvania State University received a $393,250 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective March 9, 2026, with an ultimate completion date of February 28, 2031. The Burghardt Lab will conduct fundamental genomic research investigating the evolutionary mechanisms underlying facultative host-microbe mutualism, specifically examining the...
- Federal Grant Award Summary The University of Pennsylvania received a $924,095 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective April 1, 2026 through March 31, 2031. This five-year award supports fundamental research investigating the molecular mechanisms controlling actin cytoskeleton dynamics, a critical area of basic biomedical science that underpins understanding of cellular...
- Federal Project Grant Award Summary The University of Pennsylvania received a $446,875 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective August 8, 2025, with a completion date of June 30, 2030. This award supports fundamental biomedical research aimed at deciphering novel cell death mechanisms and metabolic reprogramming in response to microenvironmental stress. The research...
- Federal Grant Award Summary The University of Pennsylvania received a $900,000 collaborative research project grant from the National Science Foundation's Division of Molecular and Cellular Biosciences (CFDA 47.074 - Biological Sciences program) on September 15, 2025, with completion targeted for August 31, 2028. This award funds fundamental research to elucidate the mechanistic drivers of transcription factor (TF) functional divergence—a key evolutionary mechanism underlying cellular and...
- Federal Project Grant Award Summary Penn State University received a $349,074 Project Grant from the National Institute of General Medical Sciences under the Biomedical Research and Research Training program (CFDA 93.859), effective July 1, 2025 through March 31, 2029. The award supports the development of an advanced nuclear magnetic resonance (NMR) spectroscopy platform for analyzing acetyllysine structure and function in proteins. The research focuses on establishing generalized protocols for...
- Federal Project Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded a Project Grant totaling $425,667 to The Pennsylvania State University, effective March 1, 2026 through January 31, 2031, under the Biomedical Research and Research Training program (CFDA 93.859). This award supports fundamental research into the molecular mechanisms of chromatin remodeling and histone deacetylation, two critical enzymatic processes that regulate DNA transcription, replication,...
- Federal Project Grant Award Summary The University of Pennsylvania received a $148,050 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective May 1, 2025 through May 31, 2027. This research project investigates the mechanistic roles of protein arginine methyltransferase 1 (PRMT1) and the RNA-binding protein heterogeneous nuclear ribonucleoprotein K (HNRNPK) in regulating the spatial...
- Federal Project Grant Award Summary The University of Pennsylvania received a $487,287 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective March 10, 2026, with a completion date of January 31, 2031. The award supports fundamental research investigating novel mechanisms of circadian rhythm control that operate independently of traditional genetic feedback loops. The research...
Penn State University received a $400,969 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective April 1, 2026, through January 31, 2031. The award supports the development and advancement of phenotype control methods—computational and experimental approaches designed to guide cell phenotypes toward desired states through targeted biomolecular interventions. The research will focus on two primary phenotype control methodologies: Feedback Vertex Set (FVS) Control, which operates from interaction network data, and Stable Motif (SM) Control, which relies on dynamic system modeling. The primary deliverables include overcoming implementation barriers to each control method to enable broader scientific application. For FVS Control, the research will identify parsimonious phenotype characterizations that can reliably specify the desired state of all network nodes, leveraging existing biological knowledge to extend beyond limited biomarker data. For SM Control, the work will automate key model construction and refinement steps using an enhanced Boolean Model Refiner (BoolMore) tool to substantially reduce development timelines. These advances will facilitate applications in guided cell differentiation, cell fate changes, and targeted cell apoptosis, with potential impact across diverse biomedical research and therapeutic contexts.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $401.0k | 3/17/26 |