Project Grant R35GM163932
- The National Institute of General Medical Sciences awarded The Pennsylvania State University $419,939 on August 1, 2026, to conduct live-cell super-resolution imaging research on enhancer-mediated gene bursting under the Biomedical Research and Research Training program (CFDA 93.859). The research characterizes transcriptional condensates—assemblies of RNA Polymerase II, Mediator, and transcription activators—in mouse embryonic stem cells and examines how they regulate target gene expression...
- The National Institute of General Medical Sciences awarded The Pennsylvania State University $432,575 on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate the molecular pharmacology and physiology of ghrelin receptor functional selectivity. The research examines two clinically relevant principles of G protein-coupled receptor (GPCR) pharmacology: functional selectivity (the asymmetric engagement of intracellular transducers such as G...
- The National Institute of General Medical Sciences awarded The Pennsylvania State University $400,969 on April 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop phenotype control methods for guided manipulation of cell behavior and fate. The research advances two phenotype control approaches applicable to biomolecular systems. Feedback Vertex Set (FVS) Control, based on interaction networks underlying biological systems, will be refined to overcome the...
- This federal Project Grant award from the National Science Foundation (NSF) Engineering program (CFDA 47.041) supports research to elucidate how the fluid-like properties of tissue extracellular matrices influence cell fate decisions in response to growth factors. The $480,237 grant, awarded to The Pennsylvania State University (Penn State) on August 1, 2024, will fund the development and characterization of viscoelastic materials to study the impact of matrix viscous dissipation on cell...
- The National Institute of General Medical Sciences awarded The Pennsylvania State University $432,575 on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop and validate technologies for controlled three-dimensional protein condensation to improve cryo-electron tomography sample preparation. The project addresses air-water interface damage that compromises sample quality and limits cryo-EM applications to many biological systems. The recipient...
- The National Institute of General Medical Sciences awarded The Pennsylvania State University $407,603 on March 5, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate brain-body allostasis via longitudinal in vivo imaging. The research examines how astrocytes—non-neuronal glial cells in the brain—coordinate physiological state shifts and facilitate whole-body allostasis during stress response. The study uses simultaneous in vivo recording of...
- The National Institute of General Medical Sciences awarded the University of Pennsylvania $924,095 on April 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate molecular mechanisms controlling actin cytoskeleton dynamics. The research addresses four major knowledge gaps: the ARP2/3 complex's role in actin filament branching and regulation by nucleotide state and binding proteins; filament dynamics at barbed and pointed ends, including cooperative...
- The National Institute of General Medical Sciences awarded The Pennsylvania State University $425,667 on March 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate the molecular mechanisms of chromatin remodeling and histone deacetylation. The recipient's research program examines ATP-dependent chromatin remodelers, specifically CHD and ISWI ATPases, and sirtuins, NAD-dependent histone deacetylases, two enzyme families that dynamically regulate...
- The National Institute of General Medical Sciences awarded The Trustees of The University of Pennsylvania $881,151 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate the structural, biochemical, and biophysical properties of cytoskeletal motor proteins, specifically myosin paralogs and their interactions with regulatory partners and actin dynamics. Research activities include structural studies to explore force generation, regulation,...
- The National Institute of General Medical Sciences awarded The Trustees of The University of Pennsylvania $125,000 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to support research on membrane remodeling by membrane-bound motors. The project investigates how class I myosin (myosin-I) couples actin filaments to lipid membranes at the actin-membrane interface, bridging a gap in understanding how cells coordinate mechanical forces and membrane...
The National Institute of General Medical Sciences awarded The Pennsylvania State University $440,259 in a Project Grant (R35GM163932) on September 1, 2026, to investigate the mechanobiology of epithelial-mesenchymal plasticity. The research examines how combined effects of matrix elasticity and viscosity regulate epithelial cell plasticity and fate decisions in response to transforming growth factor (TGF)-β1 stimulation. The project synthesizes and characterizes hydrogels with independent and tunable elastic and viscous properties to systematically establish the effects of matrix viscous dissipation on gene expression and cell plasticity across a range of matrix biochemical and mechanical properties mimicking normal and diseased tissue. The work addresses how growth factor signaling and matrix mechanics coordinate to guide cells along differentiation trajectories and how matrix viscoelasticity impacts changes in focal adhesion nanoscale architecture and signaling. Performance takes place in State College, Pennsylvania, with a period of performance from September 1, 2026, through April 30, 2031. The award is classified as a Project Grant under the Biomedical Research and Research Training program (CFDA 93.859), which supports basic research increasing understanding of biological processes and laying foundation for advances in disease diagnosis, treatment, and prevention.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $440.3k | 8/14/26 |