Project Grant R35GM161340
- The National Institute of General Medical Sciences awarded The Trustees of The University of Pennsylvania $125,000 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to support research on membrane remodeling by membrane-bound motors. The project investigates how class I myosin (myosin-I) couples actin filaments to lipid membranes at the actin-membrane interface, bridging a gap in understanding how cells coordinate mechanical forces and membrane...
- The National Institute of General Medical Sciences awarded the University of Pennsylvania $924,095 on April 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate molecular mechanisms controlling actin cytoskeleton dynamics. The research addresses four major knowledge gaps: the ARP2/3 complex's role in actin filament branching and regulation by nucleotide state and binding proteins; filament dynamics at barbed and pointed ends, including cooperative...
- The National Institute of Arthritis and Musculoskeletal and Skin Diseases awarded The Trustees of The University of Pennsylvania $473,221 on September 4, 2026, under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The research investigates thin-filament length regulation in muscle sarcomeres, focusing on the structural and functional mechanisms that control filament length and its dysregulation in skeletal and cardiac muscle diseases including nemaline myopathy...
- The National Institute of General Medical Sciences awarded The Trustees of the University of Pennsylvania $438,609 on May 7, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to fund research combining gene editing with traction force microscopy to understand mechanotransduction in leukocyte motility. The research uses CRISPR-Cas9 gene editing and traction force microscopy to conduct a directed screen of molecules implicated in cell migration, specifically...
- The National Institute of General Medical Sciences (NIGMS), a component of the National Institutes of Health, awarded The Trustees of the University of Pennsylvania $555,428 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to define the mechanistic underpinnings of AAA+ disaggregases, specifically HSP104 and its partial human homolog SKD3 (human CLPB). The research program seeks to understand at a fundamental level how HSP104 couples ATP...
- The National Institute of General Medical Sciences awarded The Rockefeller University $395,499 on April 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) for research into cytoskeletal force-sensing mechanisms underlying mechanotransduction. The research develops innovative cryo-electron microscopy sample preparation and machine-learning computational analysis approaches to uncover force-dependent structural transitions in F-actin (actin filaments) elicited by...
- The National Institute of General Medical Sciences, part of the Department of Health and Human Services National Institutes of Health, awarded $366,517 to the Regents of the University of Minnesota on August 6, 2026, under the Biomedical Research and Research Training program (CFDA 93.859). The award funds investigation of myosin-based mechanisms in filopodia formation. The research examines how filopodia—dynamic, actin-rich cellular projections that enable cell navigation, intercellular contact...
- The National Institute of General Medical Sciences awarded The Salk Institute for Biological Studies $515,625 on June 12, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate fundamental mechanisms of cytoskeletal dynamics and transport, with focus on how connector proteins link molecular motors to cellular cargo and facilitate transport along microtubule tracks. The research examines two primary areas: the role of spectraplakin proteins, which link...
- The National Institute of General Medical Sciences awarded The Trustees of the University of Pennsylvania $446,875 on March 6, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to characterize the molecular determinants of voltage-gated ion channel localization and function. The project investigates how the Golgi-associated phosphoprotein 3 (GOLPH3) coordinates transport, stability, and activity of voltage-gated sodium and potassium channels at the cell plasma...
- The National Institute of General Medical Sciences awarded The Trustees of The University of Pennsylvania $424,513 on August 15, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) for systems biology research into metabolic support of cell proliferation. The award is a Project Grant under the MIRA (Maximizing Investigators' Research Award) authority. The funded research applies systems biology approaches to develop a holistic understanding of how cells coordinate...
The National Institute of General Medical Sciences awarded The Trustees of The University of Pennsylvania $881,151 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate the structural, biochemical, and biophysical properties of cytoskeletal motor proteins, specifically myosin paralogs and their interactions with regulatory partners and actin dynamics. Research activities include structural studies to explore force generation, regulation, and mechanochemical sensing; biochemical measurements to examine chemical mechanisms and protein interactions; and single-molecule force spectroscopy to analyze how myosin paralogs respond to applied mechanical loads and influence actin network assembly. The work focuses on mechanochemical diversity within the myosin-I family, expansion of studies on MYO19 (a motor protein critical for mitochondrial function), force-velocity relationships of non-muscle myosin-II paralogs, mechanical interactions between myosins and their binding partners, and how myosin-generated force modulates actin polymerization and network force generation. Findings will provide insights into mechanochemical transduction by the actomyosin cytoskeleton with implications for understanding biological processes and informing therapeutic development. Performance occurs in Philadelphia, Pennsylvania, with a period of performance from September 1, 2026, through May 31, 2031. The award is classified as a Project Grant.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $881.2k | 8/14/26 |