Project Grant R35GM163658
- Federal Project Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded the University of California, San Diego a $479,738 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) for the period May 1, 2026 through April 30, 2031. This award supports investigator-initiated basic research focused on advancing understanding of kinetochore machinery and chromosome segregation during cell division. The research aims to characterize how...
- Federal Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded UC San Diego a $125,000 Project Grant (CFDA 93.859: Biomedical Research and Research Training) effective July 1, 2026, through June 30, 2028, to conduct research on the biophysical mechanisms linking mechanotransduction and cell morphology. The project investigates how cells respond and adapt to biochemical and physical environmental cues, with particular emphasis on nuclear translocation of...
- Federal Project Grant Award Summary The University of California, San Diego received a $440,000 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective July 1, 2026, through February 28, 2031. This award supports fundamental research on membrane-protein interactions that control mitochondrial morphology and function. The research deliverables include the development of multiscale...
- Federal Project Grant Award Summary The University of California, San Diego received a $370,550 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective May 1, 2026, with a completion date of February 28, 2031. This award supports the development of the Intracellular Protein Organization Landscape (IPOL), a quantitative computational framework designed to characterize and define cell types...
- Federal Grant Award Summary The National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) awarded UC San Diego a $369,347 Project Grant beginning July 1, 2026, and extending through June 30, 2031, to conduct high-resolution structural analysis of megasynthases using cryo-electron microscopy (cryo-EM). The primary deliverables include development and application of molecular tools and probes to enable structural...
- Federal Grant Award Summary The University of California, Davis received a $431,614 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective August 1, 2025 through July 31, 2030. This award funds fundamental research investigating the regulatory mechanisms governing alpha/beta tubulin biogenesis and polymerization, with specific focus on how tubulin cofactors and microtubule polymerization...
- Federal Grant Award Summary The University of California, San Diego received a Project Grant award of $376,498 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective August 1, 2025, with a completion date of July 31, 2030. The award funds research into active genetic systems—CRISPR-based genetic technologies that bypass traditional inheritance patterns to enable self-propagating genetic elements known...
- Federal Project Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded The Salk Institute for Biological Studies a Project Grant of $515,625 under the Biomedical Research and Research Training program (CFDA 93.859), effective June 12, 2026, with completion targeted for March 31, 2031. This award funds fundamental research to decipher mechanisms governing cytoskeletal dynamics and cellular transport, with specific focus on understanding connector proteins that link...
- Federal Project Grant Award Summary The University of California, San Diego received a $211,433 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective August 1, 2026 through July 31, 2031. This research initiative will advance fundamental understanding of protein-glycan interactions through integrated structural and biophysical investigation. The project delivers three primary...
- Federal Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded UC San Diego a $249,000 Project Grant effective September 1, 2025, through August 31, 2028, under the Biomedical Research and Research Training program (CFDA 93.859). The award supports fundamental research investigating how biophysical cues—including mechanical confinement, matrix properties, and cellular morphology—regulate macrophage and T-cell behavior in tumor microenvironments. The research...
The University of California, San Diego received a $686,308 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective August 1, 2026 through April 30, 2031. The award funds investigator-initiated basic research to advance understanding of cytoskeletal organization mechanisms critical to cell division and development. The research integrates experimental work in C. elegans embryos and cultured human cells to investigate how microtubule- and actomyosin-based cytoskeletal networks are spatially regulated during cell division and morphogenetic processes. The funded research focuses on two primary scientific areas: (1) investigation of the E3 ubiquitin ligase TRIM37 and its role in preventing ectopic spindle pole formation through degradation of centrosomal protein CEP192, with implications for synthetic lethal cancer therapies; and (2) examination of actomyosin contractile ring patterning during cytokinesis, specifically how spindle-derived cues activate RhoA through the RHO GTPase exchange factor ECT-2 to establish equatorial zone formation. The research generates fundamental knowledge of cell division mechanisms while exploring potential therapeutic vulnerabilities in TRIM37-overexpressing cancers when combined with PLK4 (polo-like kinase 4) inhibition.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $686.3k | 7/17/26 |