Project Grant R35GM158085
- The National Institute of General Medical Sciences (NIGMS) awarded a $361,952 project grant under the Biomedical Research and Research Training program (CFDA 93.859) to The Regents of the University of California, doing business as the University of California, Berkeley (UC Berkeley). The grant supports research to systematically explore the mutational landscape of biomedically relevant proteins such as CRISPR-Cas genome editing enzymes. The goal is to develop experimental methods and machine...
- The National Institute of General Medical Sciences (NIGMS) awarded a Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to the University of California, San Diego (UCSD) in the amount of $380,725 on May 5, 2025. The grant will support research to understand the molecular drivers of viral receptor-binding protein (RBP) evolution, including how mutations allow RBPs to gain new functions and the factors that constrain their evolution and enhance their...
- This $198,724 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research by the University of California, Santa Cruz on the functional genetic basis of the symbiotic relationship between the Wolbachia bacteria and Drosophila fruit flies. The overarching goal is to develop a robust understanding of the evolutionary genetics and functional mechanisms underlying this host-symbiont...
- The National Institute of General Medical Sciences (NIGMS) awarded a $392,299 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to the University of California, San Diego (UCSD) to study the genomic basis of rapid and repeated adaptation in the mosquito species Aedes aegypti. The project aims to characterize the genome-wide distribution of adaptive genetic variation and patterns of selection across the mosquito genome, leveraging the species' ability to...
- The National Institute of General Medical Sciences (NIGMS) awarded a $508,315 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to the University of California, San Diego (UCSD) to investigate the molecular mechanisms required for successful developmental progression from oocyte to embryo during a critical window of transcriptional silence in mammals. The overarching goal is to uncover post-transcriptional regulatory mechanisms, such as mRNA poly(A) tail dynamics, that...
- The federal Project Grant award of $420,984.00 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research to develop statistical methods for analyzing deep mutational scanning (DMS) data. The research aims to improve the interpretation of DMS experiments, which can measure how genetic variants affect protein function, in order to better understand the mechanisms underlying basic biology and...
- The National Institute of General Medical Sciences (NIGMS) awarded a $347,086 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to the University of California, San Diego (UCSD) to develop "Precision, Functional Glyconanoassemblies Through Supramolecular Design." This research aims to advance the state-of-the-art in synthetic glycan assemblies by employing a coordination-driven self-assembly approach to create multivalent glycomolecules with atomic...
- The National Institute of General Medical Sciences (NIGMS) awarded a $501,917 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to Purdue University. The grant supports research dedicated to elucidating the molecular mechanisms of RNA-guided biological systems, with a focus on CRISPR-associated transposons (CATs) and emerging RNA-guided gene regulation functions. The research aims to dissect the complex interactions and structural dynamics of these natural...
- This $408,375 federal Project Grant awarded on August 18, 2025 by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research to uncover the rules governing the spread of mobile genetic elements (MGEs) in microbes. The project aims to characterize MGE compatibility and how MGEs and microbial chromosomes co-evolve to maintain compatibility, using plasmids in the Agrobacteria/Rhizobia complex as a model...
- This federal Project Grant award of $380,070.00, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports a research project titled "ACTIVE CHROMOSOME MOVEMENT IN MEIOTIC PAIRING" at the University of California, San Francisco (UCSF). The project aims to investigate the cellular mechanism of meiotic pairing, testing hypotheses regarding the role of telomere-led active motion and nuclear...
The National Institute of General Medical Sciences (NIGMS) awarded a $376,498 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to the University of California, San Diego (UCSD) for a 5-year research program from August 1, 2025 to July 31, 2030. The research will focus on developing new active genetic systems that can function in both germline and somatic cell contexts. This includes exploring the use of CRISPR-based gene drive systems to potentially combat insect vector-borne diseases, crop pests, and insecticide resistance, as well as investigating the potential to restore function of disease-causing heterozygous mutant alleles through somatic cell gene copying. The research aims to advance scientific understanding and technological innovation in the field of active genetics with applications for human health and agriculture.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $376.5k | 7/28/25 |