Project Grant R35GM160211
- This federal Project Grant award of $667,480.00 was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) to St. Jude Children's Research Hospital Inc. The award supports fundamental scientific research and advanced training focused on understanding the regulation of genome expression by chromatin and how mutations in chromatin proteins contribute to oncogenesis. The research aims to provide new insights...
- The National Institute of General Medical Sciences (NIGMS) awarded a $2,503,299.00 Project Grant under CFDA 93.859 - Biomedical Research and Research Training to St. Jude Children's Research Hospital Inc. The grant, titled "Developing and Discovering Covalent Inhibitors through Fragmentation-First Experimentation", aims to leverage a novel chemical framework to dramatically simplify access to small molecules and accelerate the processes for studying their interactions with...
- This federal Project Grant award of $508,750.00, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research at St. Jude Children's Research Hospital Inc. to uncover the epigenetic mechanisms that underlie stem cell fates during embryogenesis. The research focuses on understanding how histone H3 lysine 27 (H3K27) modifiers respond to intrinsic and external cues to dynamically change H3K27...
- The National Institute of General Medical Sciences (NIGMS) awarded a $462,500 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to St. Jude Children's Research Hospital Inc. in Memphis, TN. The grant will support a 5-year research project to decipher the genetic regulation of bacterial heterogeneity in response to antibiotic stress using single-cell transcriptomics. The research aims to comprehensively characterize bacterial heterogeneity and identify genetic regulators...
- This federal Project Grant award for $226,608.00 was provided by the National Cancer Institute under the Cancer Research Manpower (CFDA 93.398) grant program. The award supports research conducted by St. Jude Children's Research Hospital Inc. to investigate the mechanism by which a specific gene regulates chromatin function and its implications for the viability of rhabdoid tumors. The research aims to elucidate how the loss of this gene further disrupts the balance between the SWI/SNF chromatin...
- This $423,890 Project Grant was awarded on September 1, 2025 by the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859). The grant is being used to support fundamental scientific research and advanced training focused on understanding the mechanisms underlying the survival and uncontrolled proliferation of stem cells with DNA damage, and the influence of surrounding tissues on stem cell behavior during tissue...
- The Children's Hospital Medical Center in Cincinnati, Ohio was awarded a $510,390 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The grant, with a performance period from May 10, 2025 to March 31, 2030, supports the hospital's research program to determine how homeodomain transcription factors specify different developmental outcomes despite binding highly similar DNA sequences. The research...
- This Project Grant award of $451,259.00 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports research to illuminate the role of chromatin composition and regulation in the repair of double-strand breaks in heterochromatin. The research, conducted by the University of Southern California, aims to: 1) establish the function of "silent" chromatin marks in promoting early heterochromatin repair;...
- This federal Project Grant award from the National Cancer Institute (CFDA 93.393 - Cancer Cause and Prevention Research) to St. Jude Children's Research Hospital Inc. provides $718,113 to fund research on "Targetable Epigenetic Modifiers that Promote Neuroblastoma Malignancy and Plasticity". The project aims to investigate how epigenetic factors, including histone deacetylases (HDAC) and histone lysine demethylase 4 family (KDM4), connect the MYC oncogenes to neuroblastoma-specific...
- The National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), awarded a $445,000 project grant to the Dana-Farber Cancer Institute, Inc. (DFCI) in Boston, Massachusetts. The grant, awarded on January 22, 2025, supports DFCI's research on the molecular mechanisms of DNA double-strand break repair by homologous recombination, a critical process for cell survival and cancer prevention. The project aims to define the complex...
The U.S. National Institute of General Medical Sciences (NIGMS) awarded a $508,750 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to St. Jude Children's Research Hospital Inc. The grant, awarded on August 1, 2025, supports research to elucidate the chromatin structure and function of double minute chromosomes (DMs) throughout the cell cycle. The project aims to develop novel biochemical and chemical strategies to investigate DM chromatin structure, mechanisms of DM-specific gene expression, and chromosome maintenance during mitosis. The research conducted at St. Jude Children's Research Hospital Inc. will provide critical insights into the role of DMs in cancer development and progression, which could inform the development of improved diagnostic and therapeutic approaches.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $508.8k | 7/31/25 |