Project Grant R35GM158501
- This $453,000 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports research to define the molecular mechanisms and cellular dynamics required to assemble a functional stem cell niche during embryonic development. The research, conducted at East Carolina University, aims to elucidate the signaling pathways, transcriptional regulators, and cytoskeletal processes that guide the migration and...
- This federal Project Grant award of $1,943,750.00, awarded on August 8, 2025, is provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The grant supports fundamental research and advanced training focused on understanding the molecular mechanisms that regulate the mitotic DNA damage response. The project, led by researchers at The Washington University, aims to 1) reveal how ubiquitinated histone H2A acts...
- This $224,088 federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports research at Harvard University to study the developmental origins of adult pluripotent stem cells. The project aims to identify the molecular and cellular mechanisms that govern the specification and maintenance of adult pluripotent stem cell populations in highly regenerative species. Specifically, the...
- This Project Grant award of $287,800 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research by the Whitehead Institute for Biomedical Research to comprehensively characterize how adult stem cell systems balance regenerative plasticity with the maintenance of discrete cell behaviors. The project aims to determine how combinatorial signaling from the stem cell niche yields distinct cellular states,...
- The National Institute of General Medical Sciences (NIGMS) has awarded a $536,250 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to the Sanford Burnham Prebys Medical Discovery Institute (SBP). The project aims to develop computational methods that can analyze single-cell transcriptomic data to better identify and study rare cell populations, such as tissue stem cells, senescent cells, and tumor-initiating cells. The approach will use...
- This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $504,175.00 to Yale University to conduct research on the role of non-coding RNA in the regulation of pluripotent stem cell biology. The research program leverages the study of planarian stem cells to investigate how non-coding RNA, particularly PIWI-interacting RNAs (piRNAs), regulate processes like maintenance of...
- This $428,600 federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports an investigation into how RNA-directed feedback loops coordinate wound healing and regeneration. The research project aims to understand the conserved developmental pathways and heterochronic genes that regulate cell migration, fate, and timing during normal adult wound repair and regeneration,...
- This $440,000 Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports a research program to investigate the ubiquitin and autophagy pathways, which are essential cellular processes involved in proteostasis or protein homeostasis. The research team at the Sloan-Kettering Institute for Cancer Research aims to uncover novel regulatory mechanisms within the ubiquitin system and enhance...
- The National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), awarded a $445,000 project grant to the Dana-Farber Cancer Institute, Inc. (DFCI) in Boston, Massachusetts. The grant, awarded on January 22, 2025, supports DFCI's research on the molecular mechanisms of DNA double-strand break repair by homologous recombination, a critical process for cell survival and cancer prevention. The project aims to define the complex...
- This federal Project Grant award, valued at $107,838.00, was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The award will support research by Northwestern University to reconstruct the ancestral gene regulatory network underlying neural crest stem cells and pluripotent blastula stem cells in vertebrates. This work aims to advance the understanding of how stem cell attributes are controlled and how...
This $423,890 Project Grant was awarded on September 1, 2025 by the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859). The grant is being used to support fundamental scientific research and advanced training focused on understanding the mechanisms underlying the survival and uncontrolled proliferation of stem cells with DNA damage, and the influence of surrounding tissues on stem cell behavior during tissue renewal. The research leverages an experimental model system based on planarian flatworms to analyze stem cell response to DNA double-strand breaks and the evolution of a cancer phenotype. The findings from this research are expected to provide new insights into the complex dynamics of tissue renewal and cellular transformation, with potential long-term implications for disease diagnosis, treatment, and prevention.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $423.9k | 8/7/25 |