This $445,000 Project Grant awarded on January 22, 2025 by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research on the molecular mechanisms of DNA double-strand break repair by homologous recombination. The principal investigator's laboratory at the Dana-Farber Cancer Institute, Inc. in Boston, Massachusetts will use the funding over the next 5 years to study the complex biochemical processes involved in homologous recombination, with a focus on elucidating the regulation of transient HR intermediates. The research aims to contribute to improved treatments for diseases associated with defective DNA double-strand break repair. The grant recipient leverages a Xenopus laevis egg extract system to reconstitute and interrogate vertebrate homologous recombination pathways in vitro, applying complementary proteomics and single-molecule imaging techniques.
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